| 1 |
Genome-wide methylation profiles reveal quantitative views of human aging rates |
marker:450000; individual:19,101,656 |
| 2 |
American College of Sports Medicine position stand. Exercise and physical activity for older adults |
section:1,2,3; guideline:2008 |
| 3 |
Cortisol levels during human aging predict hippocampal atrophy and memory deficits |
year:5 |
| 4 |
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction |
icam:-1 |
| 5 |
Aging of blood can be tracked by DNA methylation changes at just three CpG sites |
site:102; cpgs:3; sample:151; year:5 |
| 6 |
Measures of brain morphology and infarction in the framingham heart study: establishing what is normal |
participant:2200; year:34,97; age:50; volume:12; lobe:9 |
| 7 |
Distinct DNA methylomes of newborns and centenarians |
microarray:450000; analysis:450000 |
| 8 |
Quantification of biological aging in young adults |
human:954; time:3; decade:4; method:2 |
| 9 |
Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein |
exon:5; kb:50; transcript:2 |
| 10 |
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging |
mouse:130; parameter:2; risk:55 |
| 11 |
The association between physical activity in leisure time and leukocyte telomere length |
month:12; volunteer:2401; woman:2152; men:249; nucleotide:88,200; subject:7.1; kilobases:6.9 |
| 12 |
Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging |
cohort:2; donor:170 |
| 13 |
p16INK4A is a robust in vivo biomarker of cellular aging in human skin |
kinase:4,6; group:0,20,21,70; year:71,95 |
| 14 |
Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR |
donor:50; laboratory:2; occasion:2; value:0.9; measurement:6.45 |
| 15 |
Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects |
ca:2; aim:1; sandwich:2; male:23,66; age:61.1; calcium:-0.41,-0.14,9.46; pi:3.63; bun:-4.3,15.7; creatinine:0.69; d:2,54.8,125; oh:125; ipth:49.2; calcitonin:26; fgf23:43.8; ml:562; level:39; p:-146,0.001,562 |
| 16 |
Severely reduced production of klotho in human chronic renal failure kidney |
case:10 |
| 17 |
Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study |
individual:2453; year:-1,0.02,19,30,37,93; white:1742; american:711; participant:234; study:7.004; kb:0.024,0.033,0.039,0.063,6.735,7.296; p:0.0001,0.001; sem:7.923; unit:0.487,0.565,2.714,3.038; ltl:0.029 |
| 18 |
miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging |
gene:100; model:3,4,5,6; mirnas:4; mir-19b:7 |
| 19 |
microRNA expression patterns reveal differential expression of target genes with age |
mirnas:9,800 |
| 20 |
Association of human aging with a functional variant of klotho |
marker:2; p:0.0023,0.05; variant:6; f352v:2; population:3; ratio:2.59; level:2.9,6; increase:1.6 |
| 21 |
Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice |
mo:5 |
| 22 |
Individual variability in human blood metabolites identifies age-related differences |
y:4,7,15,29,81; metabolite:55,126; donor:30; compound:0.4,2.5,14,51; anhydroglucitol:15 |
| 23 |
Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic progenitors |
ml:2,4; patient:57; men:15,31,83; cell:55000000,64000000; p:0.002,0.02,0.3 |
| 24 |
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein |
kilobases:50; exon:5; site:4; kl:2 |
| 25 |
Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study |
white:450; american:185; year:31.4,37.4; baseline:1995,1996; examination:2001,2006 |
| 26 |
The effects of social status on biological aging as measured by white-blood-cell telomere length |
twin:1552; base:163.2; bp:14,22.9; pair:17 |
| 27 |
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease |
gene:340; year:20,99; region:4; case:81 |
| 28 |
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions |
site:90 |
| 29 |
Age-related changes in microRNA levels in serum |
year:30,64; mir-151a-5p:3; individual:20 |
| 30 |
Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening |
site:5; dihydro-2:8; oxodg:8 |
| 31 |
Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging |
aa:50; g:1 |
| 32 |
Determinants of telomere length across human tissues |
sample:6391; type:20; individual:952 |
| 33 |
Telomere length in different tissues of elderly patients |
leukocyte:3; patient:9; year:73,95; bp:-596,-519,6546; skin:7792; p:-420,0.001,0.006,0.01,0.04; tissue:2,7910; r:0.017,0.038,0.49,0.81,2; value:0.54,0.79 |
| 34 |
Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration |
denaturation:1994; site:11; cartilage:51; yr:41; mg:0,2,3,4 |
| 35 |
Long-term caloric restriction ameliorates the decline in diastolic function in humans |
subject:25; age:53; year:4.6,6.5,12; beta:1; group:102,131; pressure:61; hg:0.3,0.5,1.9,2.8,6,6.9,7.1,11,35.4,83; l:0.8,1,1.5; ml:29.4 |
| 36 |
Telomere length and mortality: a study of leukocytes in elderly Danish twins |
twin:548; pair:204,274; year:3,4,9,10,73,94,1997,2007; mtrfl:0.59,0.6,0.66,25,50; author:25; ci:0.49,0.52,0.53,0.56,0.63,0.66,0.67,95; interval:95 |
| 37 |
Resistance exercise reverses aging in human skeletal muscle |
n:25,26; sample:14; month:6; p:0.001; gene:596; off:5 |
| 38 |
Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging |
year:70 |
| 39 |
Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study |
resident:1000000; period:2004,2009; end:2009 |
| 40 |
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle |
biopsy:66; year:25,93; deoxyguanosine:8 |
| 41 |
Electrophysiologic and electroanatomic changes in the human atrium associated with age |
year:1,1.7,2.1,30,31,50,59,60,65; patient:13,15,24.7,66.4; atrium:500,600; m:400 |
| 42 |
Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism |
profiling:1; epetre:89; hode:9 |
| 43 |
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults |
year:50,69; month:3 |
| 44 |
Changes in bone structure and mass with advancing age in the male C57BL/6J mouse |
week:6,60; month:6,12,24; thickness:-12 |
| 45 |
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain |
flb:457; subject:24; year:19,74; decline:13; p:0.001,0.01,0.05; cortex:9,10,11; hippocampus:10; amygdala:7; thalamus:5,6 |
| 46 |
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease |
factor:11 |
| 47 |
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing |
year:30,104; discovery:58; replication:240; probe:6,16571; model:95; pathway:0.05,7,1065; p:0.002 |
| 48 |
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age |
men:13,67; woman:8,17,84; yr:40,70; mg:50; month:3,6; subgroup:5; h:24; min:20; week:2; increase:2 |
| 49 |
Loss of Brain Aerobic Glycolysis in Normal Human Aging |
year:20,82 |
| 50 |
Basal cortisol levels and cognitive deficits in human aging |
subject:19; year:4 |
| 51 |
Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity |
jew:525; probands:216; year:5,79,95; individual:309; total:51,94; p:0.0002,0.004,0.008,0.05,79; age:0.01; ci:1.18,1.57,2.55,4.49,5.88,29.41,30.65,95,368; ratio:1.23,1.98; population:2; fold:2.15; increase:1.35,14.97 |
| 52 |
A meta-analysis of cortisol response to challenge in human aging: importance of gender |
june:1966,2003; study:45; n:670; year:28; subject:-5; response:-6; d:0.24,0.42,0.65; ci:0.02,0.26,0.34,0.47,0.57,0.97,95 |
| 53 |
Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule |
year:5.8,6.6,12.4,20; survey:3; interval:3; cross:24.6,25.4; y:23,23.6,31,47; s3:0.001 |
| 54 |
Deep biomarkers of human aging: Application of deep neural networks to biomarker development |
dnn:21; sample:60000; accuracy:81.5,83.5; r:0.8,0.82,0.9,2; year:5.55,6.07,10; ensemble:0.91; marker:5 |
| 55 |
Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy |
study:2; year:2; reduction:25; participant:225; index:22; kg:28; m:2; cr:25; month:6 |
| 56 |
Regional cerebral blood flow and oxygen consumption in human aging |
patient:27; year:19,76; structure:7; cbf:0.02; yr:50; matter:17,18; p:0.05 |
| 57 |
Autophagy has a key role in the pathophysiology of schizophrenia |
light:1; lc3:3 |
| 58 |
Aging and dark adaptation |
adult:94; bleach:98; age:49; log:0.02; unit:0.3; decade:2.76 |
| 59 |
Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome |
family:2; baf:1 |
| 60 |
The Th17/Treg balance is disturbed during aging |
cell:17; il:-17; group:4 |
| 61 |
Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation |
year:18,60,91; formation:2; prostaglandin:2; receptor:2; thromboxane:2 |
| 62 |
Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men |
flow:26; year:-1,10,65; reduction:-47,-40,-37,-36,-7; p:-69,-3,0.001,0.01,0.05; men:910; increase:-103,565; pg:-84,-13; group:2 |
| 63 |
Human aging magnifies genetic effects on executive functioning and working memory |
polymorphism:2; task:2 |
| 64 |
The mellow years?: neural basis of improving emotional stability over age |
decade:7; year:12,79; m:150,200 |
| 65 |
Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys |
year:3,5,25,27; hydroxylase:50.3; neuron:33.2 |
| 66 |
Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases |
traf-2:2 |
| 67 |
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene |
d:125; hydroxyvitamin:25; hydroxylase:24 |
| 68 |
Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals |
individual:119,183; time:2; year:25,90; site:353; group:3 |
| 69 |
The aging hippocampus: a multi-level analysis in the rat |
month:3,12,24 |
| 70 |
Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects |
protein:2; subject:65; year:100,2500; time:7,8 |
| 71 |
Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys |
monoclonal:3; rat:2; igg:1; kda:130; protein:20 |
| 72 |
Neuronal changes in normal human aging and Alzheimer's disease |
year:30 |
| 73 |
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring |
methylation:1; centenarian:21; offspring:21; woman:21; island:2; hypermethylation:1; gene:2 |
| 74 |
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat |
dawley:18; libitum:42; al:4,18; cr:18; mo:18; p:0.01,4,18,32; fm:-6,0.001,45,65; vf:-0.6,7.8; g:-3.3,12.3; mu:1.4,18; kg:-0.13,-0.12,-0.1,0.51,0.75,1.41; rat:18; min:0 |
| 75 |
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice |
mouse:18; p:0.03,9 |
| 76 |
Age and amyloid effects on human central nervous system amyloid-beta kinetics |
year:5; age:65; participant:112; rate:2.5,10; decade:5; loss:50 |
| 77 |
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo |
mouse:2002; yanagisawa:175; like:1,2; enzyme:4 |
| 78 |
Elevated muscle TLR4 expression and metabolic endotoxemia in human aging |
diabetes:2; tlr4:4; month:4 |
| 79 |
Quadriceps muscle strength, contractile properties, and motor unit firing rates in young and old men |
age:12,13; year:26,80; degree:94,96; level:10,25,50,75; mvc:10,100; hz:8,26 |
| 80 |
The companion dog as a model for human aging and mortality |
specie:2 |
| 81 |
Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists |
y:21,40; individual:65; tlr7:8 |
| 82 |
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease |
dog:23; year:2.8,8.1,12.4; group:4; nitrotyrosine:3; hne:4 |
| 83 |
Reduction in regional cerebral metabolic rate of oxygen during human aging |
volunteer:22; year:26,64; structure:40 |
| 84 |
Subchondral bone in osteoarthritis |
cm:1,2,4 |
| 85 |
Myostatin is associated with age-related human muscle stem cell dysfunction |
yr:9,213,704; h:48; cell:35,67; protein:2 |
| 86 |
Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans |
h:24; increase:72; adult:87; group:3; finger:1 |
| 87 |
Heterogeneity of Human Aging and Its Assessment |
measure:5; participant:1013; year:6; index:2; frailty:3 |
| 88 |
TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity |
diabetes:2 |
| 89 |
Critical decline in fine motor hand movements in human aging |
group:2; year:18,58,60,61,94; range:38,56; p:0.0001,0.0007,0.01; measure:0.0001,2; r2:0.5,0.63 |
| 90 |
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia |
enhancer:4646; promoter:3091 |
| 91 |
Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging |
method:15; volunteer:25; year:20,68; magnitude:-6; lobe:4; word:250 |
| 92 |
Metformin extends C. elegans lifespan through lysosomal pathway |
diabetes:2; hub:2 |
| 93 |
Brain pathologies in extreme old age |
case:49; study:17; cohort:11; range:102; year:98,107; pathology:62 |
| 94 |
Genome-wide DNA methylation changes with age in disease-free human skeletal muscle |
end:3 |
| 95 |
Variability of motor unit discharge and force fluctuations across a range of muscle forces in older adults |
adult:11,14,17.3; unit:78; p:0.001,0.05,21.5; cv:1.6,7.7,8.1; subject:2.53; r2:0.06,0.2,0.3 |
| 96 |
Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan |
cohort:73,1972; member:954; biomarkers:18; age:26,32 |
| 97 |
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging |
week:6,8 |
| 98 |
Human Aging and Longevity Are Characterized by High Levels of Mitokines |
fgf21:21; gdf15:15; subject:693; year:21,70,113 |
| 99 |
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
year:21,78; mutation:13 |
| 100 |
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1 |
oxogaunine:8,78; oxoguanine:8; incision:8; fork:3 |
| 101 |
Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life |
wk:2,4,120; mouse:10 |
| 102 |
Genome-wide association study of relative telomere length |
individual:3554; snp:64; allele:-0.03; p:0.003; power:80; estimate:0.1; frequency:0.15 |
| 103 |
The effects of physical activity, education, and body mass index on the aging brain |
subject:96,226; m:3.6,77.9; volume:2,2.5,3 |
| 104 |
Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging |
august:2015 |
| 105 |
Executive system dysfunction in the aged monkey: spatial and object reversal learning |
monkey:5,7; year:6,11,20,28; group:2 |
| 106 |
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging |
oxoguanine:8; glycosylase:-1; protein:-1 |
| 107 |
Genome-wide miRNA signatures of human longevity |
mirnas:8,16,64,80,863; centenarian:15; year:36.9,45.9,96.4; individual:55; biomarkers:8; lli:15; participant:17; age:101.5; value:10; analysis:-5 |
| 108 |
Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise |
min:5,100; minute:20,60; men:15,28; age:13,15; year:-2,-1,27,62; response:65; p:0.05,20,225; intervention:8; month:3 |
| 109 |
Klotho is a serum factor related to human aging |
protein:60; year:0,91 |
| 110 |
Connection between B lymphocyte and osteoclast differentiation pathways |
way:2 |
| 111 |
Concord grape juice supplementation and neurocognitive function in human aging |
week:16 |
| 112 |
Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women |
month:5; baseline:11; pair:8; y:3.4,72.9; kg:2.4,30.6; sample:12,20; magnification:20; strength:-0.74,-0.73,0.74; m:400; r:-0.78,4; post:3.4,5.47; count:1.1,2.17 |
| 113 |
Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction |
mouse:6; month:4,6,24,28; g3:3; tempol:1; hydroxypiperidine:6 |
| 114 |
Plasma antioxidants and longevity: a study on healthy centenarians |
subject:32,34; year:60,79,80,99; adult:24 |
| 115 |
Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin |
dr:0.01,0.1,1,5,10,50; protocol:100; microdialysis:4; men:24; yr:1,12,23,53; inhibition:0.001,2,53; p:0.03,0.05,2,60; vasodilation:6,52; max:0.013,2,3,4,68,92,93,100; perfusion:50; cohort:3,4,83 |
| 116 |
A method for measuring the distribution of the shortest telomeres in cells and tissues |
kb:1,18 |
| 117 |
With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its diurnal amplitude flattens |
male:22; subject:11; year:23,24,81,85; hour:1.3,24; minute:10,30; p:0.0001,0.005,0.006,0.01,0.02 |
| 118 |
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults |
year:70; participant:14; hour:2; fdr:0.05; gene:146,647 |
| 119 |
The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging |
subset:2 |
| 120 |
The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma |
month:16,21; year:60,65,69,100; dioxygenase:23; ido:1; l1:1 |
| 121 |
Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age |
analysis:2,5,36; protein:32,1128; study:3; subject:3301; year:18,76 |
| 122 |
Activin type II receptor signaling in cardiac aging and heart failure |
fstl3:3 |
| 123 |
Sex-specific influence of aging on exercising leg blood flow |
dn:2; microcirculation:13,315,327,2006; men:31,60; yr:13,15,20,30,79; woman:16,18; min:3; rate:4.8; stage:8; p:-1,0.01,0.02,0.06,0.56 |
| 124 |
Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung |
subject:49; year:16,80,85; p:0.005; fold:2.6; age:20; oh:8; increase:0.0005 |
| 125 |
Telomere length regulates ISG15 expression in human cells |
gene:15 |
| 126 |
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity |
parent:606059; region:2; chrna3:5; month:7,11; year:1 |
| 127 |
Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits |
adult:5221; micrornas:80,127; p:3.31,4,4.21,5; expression:0.3; r:0.2; difference:1.1 |
| 128 |
Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds |
mtdna:1; gene:2; interaction:3; strain:2; zimbabwe:20; substitution:20,40,80,500 |
| 129 |
Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging |
adult:40,97,243; analytes:14 |
| 130 |
Impairment in abstraction and set shifting in aged rhesus monkeys |
year:65 |
| 131 |
The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42 |
acid:1,42; product:3,42; aggregate:3,42; beta:1,3,42; aggregation:1,40 |
| 132 |
P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations |
year:20,42.8,50,54.5,75,100; p:0.001 |
| 133 |
The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study |
volunteer:2036; study:1961,1970; may:15,1982; indication:2; diagnosis:1; treatment:2; decade:8; probability:0.29; ratio:3.52; interval:1.93,6.42,95 |
| 134 |
A human protein interaction network shows conservation of aging processes between human and invertebrate species |
homologs:175; protein:2163,2338; interaction:3271; partner:18.8; frap1:18; gene:18; span:33 |
| 135 |
Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility |
frail:19; metabolite:5,131; marker:5,6,12,22 |
| 136 |
Rearranged mitochondrial genomes are present in human oocytes |
mtdnas:100000; bp:4977 |
| 137 |
Aging of the cerebral cortex differs between humans and chimpanzees |
brain:99; y:10,22,51,88; human:87 |
| 138 |
Zebrafish (Danio rerio) as a model for the study of aging and exercise: physical ability and trainability decrease with age |
week:4 |
| 139 |
The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda |
decade:4 |
| 140 |
Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and longitudinal studies |
individual:166; group:2; year:7,21,65,69,72,79,80; subject:32 |
| 141 |
Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery |
year:-0.8,-0.5,7.1,23 |
| 142 |
The aging baboon: comparative demography in a non-human primate |
population:2; year:3.5,3.8,4.8,7,8 |
| 143 |
Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax |
dye:33342 |
| 144 |
Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging |
age:37,45,65; adult:30; monocyte:5,41; p:0.0001,0.05,150,867; ml:0.0001 |
| 145 |
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia |
beagle:100,900; year:0.25,1,2,6,11.99; age:48.2; dog:1; change:1; mechanism:2 |
| 146 |
Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human |
tissue:3; exon:1 |
| 147 |
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease |
chimpanzee:3; allele:4; predisposes:3 |
| 148 |
Effect of aging on stimulus-reward association learning |
effect:20; adult:20 |
| 149 |
Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans |
yr:1,11,29; men:1,13,39,63; peroneal:0.001,1; burst:2,23; p:0.001; r:0,0.85; lumen:82; aging:1 |
| 150 |
Kinetics of human aging: I. Rates of senescence between ages 30 and 70 years in healthy people |
number:469,54274; age:30; variable:24,445; system:13; mean:0.32,0.65; median:0.5; endocrine:3; year:30,70 |
| 151 |
Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats |
rat:1,2,3,5,6; mellitus:4 |
| 152 |
Variation in longevity gene KLOTHO is associated with greater cortical volumes |
cohort:2 |
| 153 |
CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances |
individual:19.2,30,54; year:0.5,0.7,26.1,74.6; p:0.01,0.05 |
| 154 |
Editorial |
analysis:7 |
| 155 |
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development |
year:8,15 |
| 156 |
Human Aging Is a Metabolome-related Matter of Gender |
human:150; year:100,3000; specie:2678; group:2; molecule:3,6,7,10; acid:25; phospholipid:2; prostaglandin:15 |
| 157 |
Cell-free DNA as a biomarker of aging |
utr:5 |
| 158 |
Colonic Transit Time Is a Driven Force of the Gut Microbiota Composition and Metabolism: In Vitro Evidence |
part:3; hour:48,96 |
| 159 |
Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status |
y:65,85; peptide:1 |
| 160 |
Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes |
month:18; type:3; t:3 |
| 161 |
Life-long endurance exercise in humans: circulating levels of inflammatory markers and leg muscle size |
male:15; un:12; tr:10; p:0.05 |
| 162 |
Hearts and minds: linking vascular rigidity and aerobic fitness with cognitive aging |
group:2; task:204.5,1247.9; m:0.82,3.95,211.1,898.2; velocity:3.56,8.98; max:0.036,6.92,7.31,29.04,42.32; p:0.038,0.046 |
| 163 |
Motivational Shifts in Aging Monkeys and the Origins of Social Selectivity |
goal:1,2; strength:3; lifetime:2; loss:4,5,7; activity:2; aging:8,9 |
| 164 |
A human tissue-specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence |
process:2; tissue:9 |
| 165 |
Functional Aging in Male C57BL/6J Mice Across the Life-Span: A Systematic Behavioral Analysis of Motor, Emotional, and Memory Function to Define an Aging Phenotype |
age:3,5,6,12,18; month:6,22 |
| 166 |
Extending life: scientific prospects and political obstacles |
percent:40 |
| 167 |
Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan |
sensitivity:80 |
| 168 |
Exogenous Hsp70 delays senescence and improves cognitive function in aging mice |
protein:70; mo:5,9 |
| 169 |
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair |
factor:1; treatment:2 |
| 170 |
Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution |
h:3; well:96 |
| 171 |
Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine |
fischer:344; ag:0.1; mo:18; p:0.005,0.01,0.05; tissue:0.05; ratio:3; f344:0.01,0.05; age:0.05; loss:24 |
| 172 |
Hippocampal formation size in normal human aging: a correlate of delayed secondary memory performance |
age:54,55,87; sample:7.9,69; p:0.001 |
| 173 |
Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning |
year:5.91 |
| 174 |
A beta40 is a major form of beta-amyloid in nonhuman primates |
monkey:11; year:59; plaque:2.08; ratio:0.001,0.37; ad:68 |
| 175 |
Aging is associated with highly defined epigenetic changes in the human epidermis |
set:75 |
| 176 |
Microstructural white matter changes in normal aging: a diffusion tensor imaging study with higher-order polynomial regression models |
subject:346; year:25,81 |
| 177 |
Transcriptomic profiles of aging in purified human immune cells |
participant:1264; year:55,94; gene:0.01,15,188,383,2704; network:6; pathway:3; site:17; p:0.05; fdr:30 |
| 178 |
Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender |
age:40; year:5,8,34,69; mean:20 |
| 179 |
Stochastic epigenetic mutations (DNA methylation) increase exponentially in human aging and correlate with X chromosome inactivation skewing in females |
subject:178; year:3,106; time:3; iqr:3; age:0.41; correlation:0.0053,0.14; value:0.68 |
| 180 |
Deficits across multiple cognitive domains in a subset of aged Fischer 344 rats |
rat:344; domain:2 |
| 181 |
Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process |
locus:2 |
| 182 |
A longitudinal study of DNA methylation as a potential mediator of age-related diabetes risk |
diabetes:2; woman:43; array:450; timepoints:3; cpgs:353; p:0.0012,0.0073,0.033; participant:157 |
| 183 |
Early brain response to low-dose radiation exposure involves molecular networks and pathways associated with cognitive functions, advanced aging and Alzheimer's disease |
cgy:10; gy:2; component:2; p:10; gene:-53; pathway:9 |
| 184 |
Death, taxes, and trapeziometacarpal arthrosis |
aim:1; evidence:2,3; patient:3,2321; year:10,31,71,80,81,91,93; department:2002,2012; point:3 |
| 185 |
Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility |
glp-1:1; y:8,65,80; men:7,20,34; kj:12.1; min:120; p:-0.6,-0.2,0.0001,0.004,3.2,5.3; value:4.7; result:-0.2; concentration:-0.5,0.048,7.1 |
| 186 |
Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin |
deletion:4977; hydroxy-2:8; dg:8; year:60 |
| 187 |
A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks |
gene:5,17; mouse:2 |
| 188 |
Contribution of proteoglycan osmotic swelling pressure to the compressive properties of articular cartilage |
relationship:2 |
| 189 |
Age changes in pure-tone hearing thresholds in a longitudinal study of normal human aging |
male:813; year:15,20,50,70,80,95; frequency:11; khz:0.125,0.5,2,8; period:1968,1987; age:2,6; group:7; loss:5.1,5.7,7.6,10,12.7,22.9,35.2,48.5,53,69,84.5 |
| 190 |
FOXO3 gene variants and human aging: coding variants may not be key players |
variant:38; misalignment:6; chromosome:2; gly566ala:3 |
| 191 |
Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging |
year:4,15 |
| 192 |
Effects of human aging on patterns of local cerebral glucose utilization determined by the [18F]fluorodeoxyglucose method |
subject:40; year:18,78; mumol:6.1,26.1,100; sd:40; age:18,78; cmrglu:26 |
| 193 |
Enumeration of human peripheral blood dendritic cells throughout the life |
subset:2 |
| 194 |
Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm |
bp:4977; fraction:5; mtdna:4977 |
| 195 |
The lifetime occurrence of Herpes zoster and prevalence of post-herpetic neuralgia: A retrospective survey in an elderly population |
woman:537; men:534; age:3,60,70,80; quarter:23.8; subject:3.6,15,39; third:2; month:3,12,504; factor:2; gender:1,2; p:0.009; population:64,9280000.0; people:0,200; copyright:1999 |
| 196 |
Salivary cortisol and memory function in human aging |
year:3; person:79; age:-7,78; time:3; subject:46 |
| 197 |
Naive T cells in the elderly: are they still there? |
family:24 |
| 198 |
COBRA: A prospective multimodal imaging study of dopamine, brain structure and function, and cognition |
adult:181; year:10,64,68; occasion:3; c:11 |
| 199 |
Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein |
bp:1100; day:7; acid:328; motif:2; amino:132; muscle:2 |
| 200 |
Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells |
pathway:65 |
| 201 |
Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance |
year:3,4,5 |
| 202 |
Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly |
set:10,78; change:7; total:80,83; gene:3 |
| 203 |
Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging |
monkey:31; year:5,8,12,17,21,27; sign:2 |
| 204 |
Serum factors in older individuals change cellular clock properties |
group:2 |
| 205 |
N-glycomic changes in serum proteins during human aging |
structure:3; year:40,50 |
| 206 |
Creatine improves health and survival of mice |
mouse:162 |
| 207 |
Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex |
decrease:2; monkey:8; year:5,10,25,32; male:2,5,6; female:3; task:3 |
| 208 |
Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle |
decade:5; year:47,62,76,82; group:2; spot:19; ca:3 |
| 209 |
Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs |
year:0.5,7 |
| 210 |
Impaired beta-cell function in human aging: response to nicotinic acid-induced insulin resistance |
age:35,60; ngt:15,16; igt:14; wk:2; stimulus:5,10; group:2,3 |
| 211 |
Health decline, aging and mortality: how are they related? |
change:1000 |
| 212 |
The gene responsible for Werner syndrome may be a cell division "counting" gene |
doubling:20,60 |
| 213 |
Structural architecture supports functional organization in the human aging brain at a regionwise and network level |
adult:47; range:18,82; r:0.73; ci:0.7093,0.8522,95; hum:2016,2661; periodical:2016 |
| 214 |
Gene expression-based drug repurposing to target aging |
drug:24 |
| 215 |
Protein carbonylation and heat shock proteins in human skeletal muscle: relationships to age and sarcopenia |
male:16; repetition:1; r:2; hsp:27,70 |
| 216 |
Effects of natural aging and gender on pro-inflammatory markers |
subject:22,100,110,1000; group:5,51,60,61,70; range:51,60 |
| 217 |
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing |
model:100; read:26700000.0; bp:9.4108; centenarian:3; control:3; mirnas:2,8,22,276; target:24; year:50,100 |
| 218 |
The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease |
individual:324; year:2,73; secretion:325; peptide:49,5000 |
| 219 |
Quantifying the lifetime circadian rhythm of physical activity: a covariate-dependent functional approach |
innovation:2 |
| 220 |
Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures |
transporter:2 |
| 221 |
Physiological neuronal decline in healthy aging human brain - An in vivo study with MRI and short echo-time whole-brain (1)H MR spectroscopic imaging |
subject:20,81; brain:1; lobe:8 |
| 222 |
Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1 |
mouse:3,8; model:3 |
| 223 |
Quantitative Translation of Dog-to-Human Aging by Conserved Remodeling of the DNA Methylome |
retriever:104; year:16; coverage:150; specie:2 |
| 224 |
Normal human aging: factors contributing to cerebral atrophy |
volunteer:15,94; year:-2.1,3; atrophy:1; age:60; factor:2; araiosis:3; gender:2 |
| 225 |
Cumulative index of elderly disorders and its dynamic contribution to mortality and longevity |
variable:32 |
| 226 |
Reduced DNA methylation patterning and transcriptional connectivity define human skin aging |
n:108; mark:450000 |
| 227 |
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease |
cohort:3; region:6; sample:1200; nucleus:27321 |
| 228 |
Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring |
centenarian:1,192; control:80; bioactivity:2 |
| 229 |
The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease |
exon:4; subject:274; polymorphism:2; homozygote:1; group:2,4; year:60; interval:2.594,95; p:0.003,1.385,4.858 |
| 230 |
beta-Amyloid (A beta) deposition in the brains of aged orangutans |
orangutan:4; year:10,28,31,36; ape:3; beta:40 |
| 231 |
Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with L-[beta-11C]DOPA |
dopa:11; subject:21; year:20,67 |
| 232 |
Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype |
age:50 |
| 233 |
Diurnal cycle of salivary cortisol in older adult men and women with subjective complaints of memory deficits and/or depressive symptoms: relation to cognitive functioning |
subgroup:3; day:2; individual:42; cycle:69; pattern:12,19 |
| 234 |
Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases |
compound:31; evidence:19; type:2 |
| 235 |
Gene pathways that delay Caenorhabditis elegans reproductive senescence |
inactivation:32; increase:19; oocyte:8; response:5; lifespan:5; expectancy:20 |
| 236 |
Power loss is greater in old men than young men during fast plantar flexion contractions |
yr:24,70,78; men:10; flexion:50; contraction:20; p:0.01,0.1,0.15,26; torque:0.01; velocity:18 |
| 237 |
Life at the extreme limit: phenotypic characteristics of supercentenarians in Okinawa |
year:99,100,105,110,112; supercentenarians:20; men:3,12,15; woman:9; cataract:42; disease:8,33; stroke:0,8; cancer:0; age:100,105 |
| 238 |
Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging |
caucasian:160,989; indicator:2; panel:3; n:539; participant:989; metabolite:10; r:0.94,0.96; rmse:3.8,4.3; hydroxypyrene:1; hydroxyphenanthrene:9; unit:1; y:0.53,0.54; age:95; rate:0.004,0.18,0.88; increase:1.17; ci:0.31,0.36,1.15,95; fdr:0.004,0.02,0.17,0.91,1.98,1.99 |
| 239 |
Variability of quadriceps femoris motor neuron discharge and muscle force in human aging |
type:2; feedback:1; mu:2,34,66,77; novis:32; mvc:0,0.012,0.3,0.4,0.5,0.6,1.01,1.21,1.44,1.47,1.74,2.7,3,10,37,54; drift:0.5; interaction:2.6,2.8,3.3,10.3; p:0.006; rt:1.2,6.6,7.7; s:0.005; isi:11.1; trial:0.74,3.3; bin:10 |
| 240 |
Memories that last in old age: motor skill learning and memory preservation |
adult:13,497; year:2,18,62,95 |
| 241 |
The plasma metabolome as a predictor of biological aging in humans |
year:5,10 |
| 242 |
Identification of novel small molecules that elevate Klotho expression |
expression:30; factor:23 |
| 243 |
Effect of chronic high-dose exogenous cortisol on hippocampal neuronal number in aged nonhuman primates |
nemestrina:16; year:18,29; d:4,6; month:12; cortisol:24 |
| 244 |
Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging |
hydroxylase:11; year:1,2,16,26,70; condition:3; cortisol:2,166; infusion:0.03; nmol:83; h:0.06,4; min:15,150; deoxycortisol:11 |
| 245 |
Human aging and spatial vision |
group:2; year:18,73 |
| 246 |
Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. I. CA1 of hippocampus |
subdivision:2; case:5,17; year:43,95 |
| 247 |
Immunoglobulin VH gene expression in human aging |
adult:3,5; mutation:3; family:4; expression:3; person:2 |
| 248 |
Left ventricular torsion, energetics, and diastolic function in normal human aging |
spectroscopy:31; subject:49; yr:20,69; abnormality:3; volume:100; diastolic:-0.72; p:0.0001,0.003,0.02; r:-0.63,-0.52,-0.3,0.34,0.44 |
| 249 |
Human aging is associated with altered TNF-alpha production during hyperglycemia and hyperinsulinemia |
min:30,180; clamp:10; index:2,7,67; bmi:21.8,24.7; kg:1,1.3,2,7,22; m:2; vivo:1; p:0.001,0.003,0.004,0.02,0.05; group:153,230; tnf:46; basal:37,42,182; tau:0.4; mass:0.88; r:0.81 |
| 250 |
Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis |
year:60 |
| 251 |
Expression of Klotho protein in the inner ear |
organ:2 |
| 252 |
Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations |
study:2; inchianti:27,56; gene:8,19,44 |
| 253 |
Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex |
gene:31; ba10:10; sample:72; year:18,67 |
| 254 |
Perturbation of wild-type lamin A metabolism results in a progeroid phenotype |
deletion:50 |
| 255 |
Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4+and CD8+T-cell responses in older adults positively correlates with response size |
function:5; individual:76; year:70; panel:2 |
| 256 |
Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta |
year:4,6,9,24,28; sleep:1 |
| 257 |
Age-associated changes in basal NF-B function in human CD4+ T lymphocytes via dysregulation of PI3 kinase |
kinase:3 |
| 258 |
Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells |
day:12 |
| 259 |
miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4 |
length:3; mutation:4; binding:3 |
| 260 |
Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness |
year:2 |
| 261 |
Quantification and characterization of grouped type I myofibers in human aging |
year:27,264,664; adult:91; p:0.05; nerve:57; e59:2018 |
| 262 |
Quantitative protein profiling of hippocampus during human aging |
plex:4; subject:16; group:4; protein:25,35,4582; light:9 |
| 263 |
Pulmonary function as a cause of cognitive aging |
year:10,19,50,85; participant:832; wave:7 |
| 264 |
The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease |
method:3 |
| 265 |
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1 |
wrn:3; segment:272,514 |
| 266 |
Impairment of thermoregulatory control of skin sympathetic nerve traffic in the elderly |
subject:11,12; increase:1; c:-8; minute:45; stimulus:2; p:0.01,0.05; group:2,3 |
| 267 |
Human agerelated cataracts: epigenetic suppression of the nuclear factor erythroid 2related factor 2mediated antioxidant system |
protein:1; group:15; year:66,80 |
| 268 |
Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models |
model:3,19 |
| 269 |
Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS) |
disease:10; gene:10,80.2; sample:1385; year:58,108; span:-4,5.27,10 |
| 270 |
Salivary cortisol levels and stress reactivity in human aging |
men:56; group:3; yr:43,86; subject:40,59; woman:70 |
| 271 |
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan |
type:4; subject:306; circrnas:4 |
| 272 |
Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging |
individual:40; apoe:4 |
| 273 |
Mouse Models to Disentangle the Hallmarks of Human Aging |
hallmark:9 |
| 274 |
Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts |
clock:4; r:0.9; year:3; timepoints:12; hypomethylation:-47 |
| 275 |
Perceived racism in relation to telomere length among African American women in the Black Women's Health Study |
study:1995; participant:997; mean:40; range:0.21,0.77,1.38; association:-0.1104 |
| 276 |
Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort |
type:2; n:1616,4013; replication:1; signal:25,139; p:-8,-6,-5,-0.38,0.001,4.51,10; sikh:2397; analysis:1; variant:3; white:2952; stage:2; study:10033,16998; factor:1 |
| 277 |
Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries |
level:-1; l:100 |
| 278 |
Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging |
blood:2539; module:3,4,5,15; p:-38,1.9,3.5,10; r:0.603,2; cell:-10; individual:3535 |
| 279 |
Taste thresholds: quality specific variation with human aging |
quality:4; adult:81; year:23,88; taste:4 |
| 280 |
Trends in serum uric acid levels 1961--1980 |
men:1141; examination:3,4; mg:5.5,6.5; mean:-1978,1975 |
| 281 |
Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle |
metabolism:7,71; effect:2; yr:1,7,21; fat:32.4; body:3.8; p:0.05; dos:0.6,1.5,3,5,6; palmitate:1; infusion:3; concentration:0.25,0.72,1.4,4.63,107; mumol:50,412; l:1.4,11.2; mass:0.33,1.3,1.7,1.9,3.01,13; oxidation:8.2; storage:1.4,6.6; group:2; word:250 |
| 282 |
Gut microbiome in Down syndrome |
person:17; pyrosequencing:454 |
| 283 |
Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging |
participant:116 |
| 284 |
Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in anonhuman primate model of aging |
year:6,8,20,25; monkey:6 |
| 285 |
Aging disrupts the neural transformations that link facial identity across views |
degree:20 |
| 286 |
Mechanisms of aging in senescence-accelerated mice |
model:2 |
| 287 |
NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system |
adult:50,100; interquartile:5.3; ir:1.4,1.7,8.74; percentage:-10; subset:2; cmv:3.1,5.3; response:2,3.4; p:0.015,0.037; production:8.8,13.7,24,40.56 |
| 288 |
Cutaneous vasoconstrictor responses to norepinephrine are attenuated in older humans |
yr:11,18,30,62,76; forearm:2; degree:34; dos:-10,5; ne:-61,-56,-40,-20,-10,-6,10; m:-2; confidence:-90,-80,-52,-35,95; deltacvcbase:-74,-70,-60,-58,-52,-40,-38,-35,-8,-6; p:0.01,0.02,0.03,10 |
| 289 |
Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men |
endothelin:-1; type:2; age:14; year:1,2,25,61; p:0.05,0.2,0.9,4.9,13.9,25; ml100:-1,0.3,0.8,1,4.6,4.8,5.1,17.2,17.3,18.5; difference:-1; men:-1; increase:20 |
| 290 |
Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia |
case:3.5,5; disease:4; patient:1; process:3 |
| 291 |
Nicotinic acetylcholine receptors during prenatal development and brain pathology in human aging |
week:4,6; year:40,100; decade:70 |
| 292 |
Airspace enlargement with airway cell apoptosis in klotho mice: a model of aging lung |
week:2,12; time:6 |
| 293 |
Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics |
cell:300; gene:100,12000 |
| 294 |
Reduced telomere length variation in healthy oldest old |
senior:85,134; individual:47,400; year:40,50,100 |
| 295 |
Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects |
caucasian:476; men:208; woman:268; year:16,104; r:-0.706,-0.601,0.27; p:0.001 |
| 296 |
Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men |
normotensive:129; year:18,77; p:0.001,0.05,0.22; r:0.55 |
| 297 |
Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal |
shmt2:2; month:9; day:13.5; dpc:12.5 |
| 298 |
Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores |
n:16,17; gene:2,100,2500 |
| 299 |
Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease |
year:80; control:20,60; age:65; n:5 |
| 300 |
The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women |
level:-1; participant:1292; men:633; woman:659; year:3 |
| 301 |
Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle |
proteome:2; d:2 |
| 302 |
Augmented forearm vasoconstriction during dynamic exercise in healthy older men |
subject:16; year:1,12,26,65; load:40,60,1100,1400; o2:0.1,1.85; min:0.07,2.38; group:2; minute:5; p:0.05; peak:1; hyperemia:20; vasoconstrictor:2 |
| 303 |
From Hayflick to Walford: the role of T cell replicative senescence in human aging |
year:40; area:2 |
| 304 |
Normal human aging and early-stage schizophrenia share common molecular profiles |
year:4,19,81; overlap:29,34 |
| 305 |
Bitter taste receptor polymorphisms and human aging |
cluster:3; chromosome:5,7,12; individual:941; year:20,106; bp:212; p:0.001; subject:20,55,70 |
| 306 |
Genetic regulation of gene expression and splicing during a 10-year period of human aging |
age:2,70,80; year:10; gene:294,529 |
| 307 |
Label-free quantitative protein profiling of vastus lateralis muscle during human aging |
protein:366 |
| 308 |
Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition? |
field:2 |
| 309 |
Age and gender differences in body composition, energy expenditure, and glucoregulation of adult rhesus monkeys |
group:3; year:7,9,13,17,23; p:0.05,0.06 |
| 310 |
Impairment of B lymphopoiesis in precocious aging (klotho) mice |
week:2,3 |
| 311 |
How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data |
variable:4 |
| 312 |
Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines |
beagle:30; year:4.5,15.7; ratio:40 |
| 313 |
The MiAge Calculator: a DNA methylation-based mitotic age calculator of human tissue types |
tumor:2221,4020; type:5,8,13 |
| 314 |
Protein associated with human lens 'native' membrane during aging and cataract formation |
year:20,37,62,80; fraction:25,45,50,58; lens:70,75 |
| 315 |
N-glycan profiling in the study of human aging |
structure:3 |
| 316 |
Heritability analysis of life span in a semi-isolated population followed across four centuries reveals the presence of pleiotropy between life span and reproduction |
community:3; se:0.02,0.15 |
| 317 |
Cytomegalovirus infection accelerates epigenetic aging |
vitality:1920; nonagenarian:122; control:21; rate:57,95; p:0.01,24,26.5,70,76 |
| 318 |
Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age |
individual:24; year:24,47; data:450; site:11,497; gene:422; blood:2316 |
| 319 |
The complexity of standing postural control in older adults: a modified detrended fluctuation analysis based upon the empirical mode decomposition algorithm |
adult:22; p:0.001; r:0.38,2 |
| 320 |
A mesenchymal stromal cell gene signature for donor age |
donor:61; age:17,84 |
| 321 |
Point mutations of the mtDNA control region in normal and neurodegenerative human brains |
individual:31,35,47 |
| 322 |
Cerebral blood flow and metabolism in normal human aging, pathological aging, and senile dementia |
year:11,21,71; subject:1956,1958; population:2; drop:22; cmrg:40; word:250 |
| 323 |
Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death |
way:2; deletion:4977 |
| 324 |
Decades of field data reveal that turtles senesce in the wild |
y:20 |
| 325 |
Parallel declines in cognition, motivation, and locomotion in aging mice: association with immune gene upregulation in the medial prefrontal cortex |
mouse:6,18; month:24 |
| 326 |
Klotho protein activates the PKC pathway in the kidney and testis and suppresses 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression |
hydroxyvitamin:25; vitamin:25 |
| 327 |
Aging leads to dysfunctional innate immune responses to TLR2 and TLR4 agonists |
tlr:2,4; ligand:4; subject:40,554; subset:250; increase:1.1,1.3,2.5; p:0.0005,0.0007,0.02,0.03,0.05,554; lp:1.9; decrease:2.1; year:2.6 |
| 328 |
Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while a... |
sulforaphane:1 |
| 329 |
Circulating Interleukin-6 Is Associated with Skeletal Muscle Strength, Quality, and Functional Adaptation with Exercise Training in Mobility-Limited Older Adults |
performance:99; adult:9; month:6; p:-0.487,-0.237,-0.211,0.05,0.69; il-6:-0.311,-0.248,-0.201; r:-0.21,0.256; pg:1.36 |
| 330 |
Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men: relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measu... |
yr:23,39,63,89; level:3; r:-0.82,-0.49,-0.42,-0.4,0.49; p:-0.79,0.001,0.002,0.01,0.02,0.025,0.37,0.9,1,15.4,20.1; secretion:-3 |
| 331 |
Erythrocyte plasma membrane redox system in human aging |
subject:80; year:18,85; correlation:0.0001; p:0.7797 |
| 332 |
Age-associated decrease of oxidative repair enzymes, human 8-oxoguanine DNA glycosylases (hOgg1), in human aging |
oxoguanine:8; dna:8; polymorphism:326; oligonucleotide:28; individual:78; year:91 |
| 333 |
Normal human aging and cerebral vasoconstrictive responses to hypocapnia |
volunteer:22; year:-65,21; atherosclerosis:1; presence:2 |
| 334 |
Time to talk SENS: critiquing the immutability of human aging |
stage:3 |
| 335 |
Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia |
group:3; n:5; year:51.2; age:5,76,79.6 |
| 336 |
Aging and Physiological Lessons from Master Athletes |
physiol:296,2020 |
| 337 |
Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women |
system:2; igfbp-3:3; men:486; yr:50,80; component:3; glucuronide:3 |
| 338 |
In human keratinocytes the Common Deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation |
deletion:4977; mutation:50000; j:12,15 |
| 339 |
Metformin Abrogates Age-Associated Ovarian Fibrosis |
mouse:0; month:33; year:21,41,71,82; cohort:2; fibrosis:27; use:523 |
| 340 |
Troglitazone improves endothelial function and augments renal klotho mRNA expression in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with multiple atherogenic risk factors |
troglitazone:200; week:10,30; p:0.05,7; acetylcholine:-5,10 |
| 341 |
Influence of age and gender in motor performance in healthy subjects |
year:11.04,40,63.61; subject:246; male:123; female:123; age:10.79,63.67; group:7; test:3,4; point:2; factor:2 |
| 342 |
Life and death of lymphocytes: a role in immunesenescence |
pathway:2 |
| 343 |
Neurofilaments of Klotho, the mutant mouse prematurely displaying symptoms resembling human aging |
al:1999; re:348; nm:35,39,48,49 |
| 344 |
Network model of human aging: Frailty limits and information measures |
max:0.7,1; q:0.3,1 |
| 345 |
Epigenetics of Aging |
methylcytosine:5; hydroxymethylcytosine:5 |
| 346 |
Interleukin 1 alpha is a marker of endothelial cellular senescent |
cytokine:1 |
| 347 |
Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta) |
variable:33; monkey:345; year:7,30; facility:3; relationship:15 |
| 348 |
Perimenopausal regulation of steroidogenesis in the nonhuman primate |
attenuation:2 |
| 349 |
Involvement of FANCD2 in Energy Metabolism via ATP5 |
aa42:72; mtatp5:72 |
| 350 |
Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity |
protein:1; polymorphism:2; subject:910; woman:475; men:435; range:40,109 |
| 351 |
Age-related changes of the functional architecture of the cortico-basal ganglia circuitry during motor task execution |
subject:59 |
| 352 |
Adipose Stem Cell Function Maintained with Age: An Intra-Subject Study of Long-Term Cryopreserved Cells |
patient:3; year:7,12; time:2 |
| 353 |
Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons |
m:150; peroxide:1.5; o:2; treatment:24; caspase:3; activity:7; rise:2 |
| 354 |
Biological effects of rutin on skin aging |
subject:40; year:30,50; density:2 |
| 355 |
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1 |
polymerase:1; response:2; process:2 |
| 356 |
Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes |
parameter:36; period:2008; score:2016; group:3; n:289; subcohort:60; october:2016; march:2017; sample:4,1993,2013 |
| 357 |
The effect of resveratrol on a cell model of human aging |
gene:47,19000 |
| 358 |
Ebbinghaus revisited: influences of the BDNF Val66Met polymorphism on backward serial recall are modulated by human aging |
adult:948 |
| 359 |
Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome |
gene:85,6912; kind:3; oxide:4; fold:3,10,40 |
| 360 |
The role of CD8 T cell replicative senescence in human aging |
year:50 |
| 361 |
Structural and functional neural correlates of visuospatial information processing in normal aging and amnestic mild cognitive impairment |
apoe:4 |
| 362 |
Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity |
mouse:1 |
| 363 |
Understanding How Dogs Age: Longitudinal Analysis of Markers of Inflammation, Immune Function, and Oxidative Stress |
retriever:80; hydroxy-2:8; level:70; response:70 |
| 364 |
A novel, population-specific approach to define frailty |
subject:680; year:3,65,108 |
| 365 |
Aging, cognition, and the brain: effects of age-related variation in white matter integrity on neuropsychological function |
adult:16,18; year:20,28,60,75 |
| 366 |
Effect of age and severity of cognitive dysfunction on two simple tasks in pet dogs |
test:2; year:1,4,5,8,9,10,31; dog:37 |
| 367 |
Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals |
cell:153,1194,2013; deletion:266 |
| 368 |
Muscle sympathetic nerve activity during cold stress and isometric exercise in healthy older adults |
stress:1; augment:2; yr:1,2,11,23,60; adult:0,0.05,1,12; contraction:30; t:1,2,3,12,14,18,20,34; p:0.05,2,3,17; burst:1,3,8,12; min:1,8 |
| 369 |
Environmental enrichment-behavior-oxidative stress interactions in the aged rat: issues for a therapeutic approach in human aging |
day:60 |
| 370 |
Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade |
acth:2,3.2,4.6; yr:8,25; bolus:200; h:4; p:0.002,0.006,0.01,0.05; dhea:0.01; time:1; hyposecretion:3 |
| 371 |
Neuropathologic analysis of Lewy-related -synucleinopathy in olfactory mucosa |
lbas:39; patient:7,37.1,105; case:6,7,8,31,75; lbd:3.2 |
| 372 |
Age-associated alterations in inducible gene transcription in human CD4+ T lymphocytes |
interleukin:1,6 |
| 373 |
Aging research 2011: exploring the pet dog paradigm |
mechanism:1; intervention:2; correlate:3; heterogeneity:4; biomarkers:5 |
| 374 |
Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress |
increase:210,320; reduction:22,29,63; pressure:8 |
| 375 |
Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism |
hfpef:12,40,50; hypothesis:2; stiffness:1,2; mechanism:2; gain:10; mlmmmhg:0.1,0.11,0.23,0.37; p:0.008,0.014; fluctuation:3; mmhg:2.9,3.8,10.4,12.2 |
| 376 |
Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging |
region:2 |
| 377 |
Evaluation of DNA methylation markers and their potential to predict human aging |
locus:2; sample:23,44; year:5,6.9,9.2,72; age:0.801,2; r:0.654,2 |
| 378 |
Human aging and CD31+ T-cell number, migration, apoptotic susceptibility, and telomere length |
yr:1,2,12,25,36,46,64; middle:12; p:0.01,0.05,40; unit:45,46,305.6,306.1; au:60,62,65,231,235,525,570; bp:192,220,251,9324,10179,10706 |
| 379 |
Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study |
decade:7; volunteer:80; participant:19,78; f:33,45; decrease:-1.7; p:0.0025 |
| 380 |
Modulation of striatal dopamine D1 binding by cognitive processing |
year:20,22,30,65,75; sch:2,11,23390 |
| 381 |
Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians |
beadchip:450; centenarian:12,30; control:12,30; site:31 |
| 382 |
Sequence and Solution Effects on the Prevalence of d-Isomers Produced by Deamidation |
form:4; isomer:4 |
| 383 |
Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction |
mouse:14,82,128; week:12 |
| 384 |
Secretome analysis of in vitro aged human mesenchymal stem cells reveals IGFBP7 as a putative factor for promoting osteogenesis |
technique:2 |
| 385 |
Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects |
donor:16; year:0,97 |
| 386 |
Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling |
body:1; degree:10,30.5; infusion:1,2; m:-6; fiber:4; y:8; subject:8; control:1; inhibition:2,3,20; rock:4; vc:-34; deltacvc:1,3,9; p:-53,-41,0,0.001,0.006,0.01,0.016,4; reduction:-30,-7,0,5; fasudil:-23,-7,0,4 |
| 387 |
Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA |
mutation:3243,5692,12246; gly:10006; sample:2,15 |
| 388 |
Teeth, sex, and testosterone: aging in the world's smallest primate |
year:3,4,5,8,12; sign:189; age:1,8; se:1.63,2.59 |
| 389 |
Human aging compromises attentional control of auditory perception |
source:2 |
| 390 |
Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging |
day:30,60; mouse:50; month:8; year:2 |
| 391 |
Real-time detection of telomerase activity using the exponential isothermal amplification of telomere repeat assay |
min:25 |
| 392 |
Tau immunoreactivity in peripheral tissues of human aging and select tauopathies |
case:2,3,5,8,55,62,69,97; psp:1,19,26; ad:1,2,3,21; specie:2; cbd:1 |
| 393 |
Season of birth and exceptional longevity: comparative study of american centenarians, their siblings, and spouses |
age:100; centenarian:1574,1880,1895; sibling:10885; spouse:1083 |
| 394 |
Neuroepigenetic signatures of age and sex in the living human brain |
pet:41; skill:23 |
| 395 |
Relationship between changes in body composition and insulin responsiveness in models of the aging rat |
rat:40; r2:0.522,0.85; p:0.01,0.05,14; insulin:18; rd:270; responsiveness:10; mo:2,4,14; decrease:20; fischer:344 |
| 396 |
Aged cells in human skeletal muscle after resistance exercise |
h:0,48; availability:2; protein:14,44; cell:-73,-48; p:0.001,0.01; supplementation:48; week:12 |
| 397 |
Change in the telomere length distribution with age in the Japanese population |
year:50; age:50 |
| 398 |
The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice |
mo:4,5,14,20,22; mouse:6 |
| 399 |
Aging: gene silencing or gene activation? |
piperidinedione:6 |
| 400 |
L-cysteine efflux in erythrocytes as a function of human age: correlation with reduced glutathione and total anti-oxidant potential |
decline:0.0001 |
| 401 |
Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome |
individual:217; patient:1,41; p:0.001; age:71; ml:0.001 |
| 402 |
TNF-alpha-induced apoptosis in human nave and memory CD8+ T cells in aged humans |
type:2; subpopulation:4 |
| 403 |
A cluster analysis to define human aging phenotypes |
year:65,85; phenotype:3 |
| 404 |
Mechanical and structural changes in human thoracic aortas with age |
aorta:76; property:13; year:78,5118; group:7; model:4 |
| 405 |
Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease. II. Subiculum |
case:5,15; year:43,95 |
| 406 |
N- and O-glycan cell surface protein modifications associated with cellular senescence and human aging |
glycans:2; structure:2 |
| 407 |
Homeostasis between lipid peroxidation and antioxidant enzyme activities in healthy human aging |
phosphogluconate:6; year:40,50 |
| 408 |
Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging |
expression:3; men:43; yr:1,16,25,27,65; support:1; buffering:2; cardiovagal:3; rate:4 |
| 409 |
Denitrosylate and live longer: how ADH5/GSNOR links mitophagy to aging |
like:1; class:5 |
| 410 |
Effects of aging on the intrinsic circadian period of totally blind humans |
year:6,38; measurement:3; h:0.08,0.13,24; participant:4,6; assessment:2; p:0.01; interval:95; decade:1 |
| 411 |
Drug repurposing for aging research using model organisms |
compound:743 |
| 412 |
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity |
exonuclease:-5,3; utr:5 |
| 413 |
Anti-Aging Effect of Riboflavin Via Endogenous Antioxidant in Fruit fly Drosophila Melanogaster |
rank:2,15.886; riboflavin:16.677; p:0.001,0.01,0.05,15; day:30 |
| 414 |
SomaMutDB: a database of somatic mutations in normal human tissues |
variation:2420000.0; insertion:120000.0; tissue:19; tool:6 |
| 415 |
Physical independence and mortality at the extreme limit of life span: supercentenarians study in Japan |
centenarian:642; age:110,207,351; year:100,105,109,110,10400; supercentenarians:84 |
| 416 |
Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the ... |
individual:12,42; month:4,7,10; year:8 |
| 417 |
Extracellular glycation crosslinks: prospects for removal |
approach:2 |
| 418 |
Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression |
v2:2; region:2; end:3 |
| 419 |
Modeling normal aging bone loss, with consideration of bone loss in osteoporosis |
year:10,25,30,50,60; decade:3,7,11; observation:1976,1980; microg:1 |
| 420 |
The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13... |
mmp:-13 |
| 421 |
Physiologically Based Pharmacokinetic Modelling to Identify Pharmacokinetic Parameters Driving Drug Exposure Changes in the Elderly |
drug:10,52; model:20; fold:1.25,1.5,70 |
| 422 |
Multiple morbidities in companion dogs: a novel model for investigating age-related disease |
year:65; dog:2000 |
| 423 |
Loss of Sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction |
microm:200,400 |
| 424 |
Acute ascorbic acid ingestion increases skeletal muscle blood flow and oxygen consumption via local vasodilation during graded handgrip exercise in older adults |
aa:1,2; protocol:1,2; yr:-16,2,3,8,10,63,65; contraction:5; fbf:4,13,24,43,199,343; ml:3,5,16,33,34,50,248,403; p:0.05; mvc:15,20,25; pressure:-40; fvc:15 |
| 425 |
Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects |
male:13,16,84; yr:30; group:2; subject:6,7,8,612,668,1649,3895,4819; session:2,3; microgram:2,87,102,563,774,1455,4743; ghrh:0.001,2; hexarelin:2; arginine:0.5; level:18.7; p:0,0.001,0.02,19.1,120,211.5,459,601,683,1057,2112,4849; min:503,7725; word:400 |
| 426 |
Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process |
b:0.0115; p:0.0001 |
| 427 |
Lifespan in captive baboons is heritable |
p:-0.08,0.0003,0.23; baboon:674 |
| 428 |
Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue |
year:21,76; subgroupings:4 |
| 429 |
Age-dependent decline in erythrocyte acetylcholinesterase activity: correlation with oxidative stress |
year:22,37,82 |
| 430 |
Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences |
decrease:1; ratio:2; reduction:3; level:4 |
| 431 |
Cellular cholesterol enrichment impairs T cell activation and chemotaxis |
pathway:2 |
| 432 |
Leukocyte telomere length and physical ability among Danish twins age 70+ |
twin:548; question:11; kb:0.066; p:0.01; year:3 |
| 433 |
Advancing front of old-age human survival |
decade:5; country:20; percentile:25,90; age:65 |
| 434 |
Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques |
age:22; area:32,46 |
| 435 |
ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age |
min:15; h:1 |
| 436 |
Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit |
m:27; subunit:2,25; month:3,12 |
| 437 |
Estimating Biological Age in the Singapore Longitudinal Aging Study |
biomarkers:8,10,68; singaporean:2844; subgroup:2; year:8,55,70,71,94; algorithm:3; second:1 |
| 438 |
Exercise increases tryptophan availability to the brain in older men age 57-70 years |
male:19; age:64; yr:3; vo:68; min:30,60,90; h:1,2.4,8.6; p:0.0001,0.001,0.05; exercise:78; moll:0.7,1.8,2.8,5.7; r:0.48,0.887 |
| 439 |
Risk, reward, and decision-making in a rodent model of cognitive aging |
rat:5,23; pellet:2; delivery:100 |
| 440 |
Complex patterns of gene expression in human T cells during in vivo aging |
donor:25; cell:25; year:95; pattern:3 |
| 441 |
A longitudinal study of human age-related chromosomal analysis in skin fibroblasts |
donor:8; chromosome:7,11,17; culture:2,16; individual:2,8; frequency:15 |
| 442 |
Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly |
aim2:2; year:16,18,20,39,60,84; dsdna:5 |
| 443 |
Decreased activity of Ca(++)-ATPase and Na(+)/K(+)-ATPase during aging in humans |
membrane:2; decrease:0.0001 |
| 444 |
Effects of caloric restriction are species-specific |
question:2; cr:1,2 |
| 445 |
Aging-related changes in cardiac sympathetic function in humans, assessed by 6-18F-fluorodopamine PET scanning |
uptake:1; volunteer:16,33; y:17,40,50; fluorodopamine:18; scanning:13; nh:3; radioactivity:18; group:48; p:0.02,74; activity:1 |
| 446 |
Basal neutrophil function in human aging: Implications in endothelial cell adhesion |
parameter:18 |
| 447 |
The expression signature of in vitro senescence resembles mouse but not human aging |
datasets:7; mouse:4 |
| 448 |
Role of Exercise on S-Klotho Protein Regulation: A Systematic Review |
gene:3 |
| 449 |
Mllerian inhibiting substance as a novel biomarker of cisplatin-induced ovarian damage |
saline:4.5; mg:6; kg:6 |
| 450 |
Age-related variations in the neuroendocrine control, more than impaired receptor sensitivity, cause the reduction in the GH-releasing activity of GHRPs in human aging |
subject:16; yr:66,81; control:12; y:24,28; microgram:1,2,3,46.3,172.8,178.1,273.6,306,308,360.8,363,387.2,482.2,528.7,1079.2,1402.6,2934.3,4259.2; gr:0.5; hex:1,336.7; auc0:406.4,1728.4,2265.9; p:0.001,0.005,0.01,0.03,0.05,111.4,117.6,792.2,2371.7; ghrh:183.8,649.6,1858.9,4009.1,4406; response:17.3,27.3,50,157.9,260.9,356.1,742.8,1205.1; kg:0.05,1; arg:2069.5 |
| 451 |
Global Network Alignment in the Context of Aging |
challenge:2; cost:1 |
| 452 |
A Longitudinal Epigenetic Aging and Leukocyte Analysis of Simulated Space Travel: The Mars-500 Mission |
participant:6; day:520; metric:5 |
| 453 |
Comparison of multi-tissue aging between human and mouse |
tissue:4,18; pair:9 |
| 454 |
Spatial reversal learning is impaired by age in pet dogs |
n:44; year:2.8,7.8,8; route:2; week:2 |
| 455 |
SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study |
year:70; participant:0.34; interval:95; ci:0.17,0.69; n:1309 |
| 456 |
Shorter telomere length in schizophrenia: Evidence from a real-world population and meta-analysis of most recent literature |
year:2 |
| 457 |
Aging-associated patterns in the expression of human endogenous retroviruses |
family:2; k:91; herv:213; rna:7; hml-2:33; locus:45; cluster:2 |
| 458 |
Aging-dependent decline of IL-10 producing B cells coincides with production of antinuclear antibodies but not rheumatoid factors |
age:19,31,39; individual:60,73 |
| 459 |
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions |
enpp1:1; level:125 |
| 460 |
Depressive symptoms, cortisol, and cognition during human aging: the role of negative aging perceptions |
adult:40; year:58,85; female:18; male:22 |
| 461 |
Passive force and viscoelastic properties of single fibers in human aging muscles |
adult:7; age:10; solution:9; isoform:2.4,4.2; t1:2; p:0.001,0.012; sl:4.2; m:4.2 |
| 462 |
Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: I. Age-dependent loss in human myocardium |
human:29; rna:18; month:3; year:76; unit:260; amount:0.5; coefficient:-0.83 |
| 463 |
Age-associated changes of cerebrospinal fluid amyloid- and tau in cynomolgus monkeys |
monkey:22,37; age:4; year:22 |
| 464 |
Age-dependent deamidation of glutamine residues in human S crystallin: deamidation and unstructured regions |
glutamine:92; decade:8; domain:2; region:2 |
| 465 |
White Matter Damage and Hippocampal Neurodegeneration Induced by Permanent Bilateral Occlusion of Common Carotid Artery in the Rat: Comparison between Wistar and Sprague-Dawley Strain |
al:2007; rat:2,14,15; g:250,270; week:3; rate:4 |
| 466 |
A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans |
phenotype:90; age:52,69,79; study:730; polymorphism:215; p:-3,510; n:4,6447; increase:22,90,99,253; score:4900; reduction:11; year:18; ratio:0.89 |
| 467 |
Arterial baroreflex control of cardiac vagal outflow in older individuals can be enhanced by aerobic exercise training |
month:6; woman:5; men:7; year:55,71; increase:26; p:0.05 |
| 468 |
Telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions |
day:7; p:0.031 |
| 469 |
A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease |
beagle:9; month:3,98,115; extract:1,5; curcuminoids:2,95; cysteine:50; acetyl:3; alpha:4; piperine:95; dog:9,13; t11:4.3; p:0.001; f:19,20.7 |
| 470 |
Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age |
homologue:1; msh2:2; year:45,86 |
| 471 |
Brain manganese concentrations in human aging and Alzheimer's disease |
microgram:0.245,0.261; difference:0.05 |
| 472 |
V2+ and / T cells show divergent trajectories during human aging |
marker:2 |
| 473 |
Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity |
individual:1112; year:20,65,89,108; variant:4,35; gene:23 |
| 474 |
Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging |
men:11,14; index:24,31,61,82; kg:19,21,30,31; month:6; level:0.1,0.2,3,5.1,5.4,6,50; airmax:14,28; si:0.6,5.1; min-1:-5,0.7,6.5,10; gezi:0.2,1.3,1.7,10; n:-2,0.2,0.4,8.8,8.9; pm:11,49,63; group:2; value:50,253; p:0.005,0.01,0.05,0.13,0.15,1.95,101,543; reduction:179,225,1277,2321; glucose:1.49; word:400 |
| 475 |
Deficits of psychomotor and mnesic functions across aging in mouse lemur primates |
murinus:41; animal:25 |
| 476 |
Alteration in N-glycomics during mouse aging: a role for FUT8 |
mouse:6; structure:3; core:-16; fut8:-16 |
| 477 |
Age-related changes in nitric oxide activity, cyclic GMP, and TBARS levels in platelets and erythrocytes reflect the oxidative status in central nervous system |
month:24 |
| 478 |
Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes |
plins:2 |
| 479 |
Precise Metabolomics Reveals a Diversity of Aging-Associated Metabolic Features |
window:5; metabolite:480 |
| 480 |
Differential proteome analysis of replicative senescence in rat embryo fibroblasts |
spot:42,49,1200; expression:2; tuc-1:-2; change:-4; beta:-4; model:2 |
| 481 |
N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model |
day:45,60,75,105 |
| 482 |
A nested case-controlled comparison of telomere length and psychological functioning in breast cancer survivors with and without insomnia symptoms |
woman:70; n:70; median:6,6.195; s:-0.269,1; se:0.287; error:0.287; p:0.001,0.29 |
| 483 |
Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains |
sample:101; region:13; year:20,70; gene:1446; rate:5 |
| 484 |
Age-Related Regional Network Covariance of Magnetic Resonance Imaging Gray Matter in the Rat |
gray:7; male:10; rat:344 |
| 485 |
Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease |
activity:2; recq:3; box:2; exonuclease:2 |
| 486 |
Sympathoadrenal-circulatory regulation of arterial pressure during orthostatic stress in young and older men |
form:2; suction:-10; mmhg:-50; yr:1,14,26; men:1,13,64; group:2; p:0.05; word:250 |
| 487 |
The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans |
associate:7 |
| 488 |
Effects of aging and dopamine genotypes on the emergence of explicit memory during sequence learning |
year:20,30,60,71,80; adult:70 |
| 489 |
Validation of a single factor representing the indicators of metabolic syndrome as a continuous measure of metabolic load and its association with health and cognitive function |
aim:3; participant:1609; year:68.5; sd:3.7; female:50.1; indicator:5; fev1:1 |
| 490 |
A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging |
centenarian:81; year:70,80,100; control:46; biomarkers:15; molecule:4; fgf:19,21; pp:1; a:0.027,11.832; chemerin:0.009; fgf21:0.014; fgf19:0.007; auc:0.94; p:0.001 |
| 491 |
Age-related human mtDNA deletions: a heterogeneous set of deletions arising at a single pair of directly repeated sequences |
class:2; bp:5,13,4977,8048; deletion:9,8037; kb:8.04; copy:1 |
| 492 |
Responses to Predictable versus Random Temporally Complex Stimuli from Single Units in Auditory Thalamus: Impact of Aging and Anesthesia |
hz:2,1024; majority:86; unit:51; p:0.0001,0.05; signal:16; sam:30 |
| 493 |
Modeling the human aging transcriptome across tissues, health status, and sex |
sample:3060,6000; value:0.96 |
| 494 |
Endocrine changes associated with the human aging process: III. Effect of age on the number of calcitonin immunoreactive cells in the thyroid gland |
patient:60; year:0.99,1.46,16,39,40,59,60,89; number:0.99; mm2:1.07,2.97,3.69 |
| 495 |
Familial mortality in the Utah population database: characterizing a human aging phenotype |
cause:10; individual:1830,1963,666921; age:40 |
| 496 |
Cathepsin B and L activity in the serum during the human aging process: cathepsin B and L in aging |
n:60; men:30; woman:30; year:20,50,80; age:20 |
| 497 |
TNF-alpha, leptin, and lymphocyte function in human aging |
n:37,42 |
| 498 |
SIR2 and aging--the exception that proves the rule |
view:2 |
| 499 |
Concise total synthesis of glucosepane |
step:8; convergent:12 |
| 500 |
T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians |
individual:51; year:20,49,70,104 |
| 501 |
A common polymorphism in the UCP3 promoter influences hand grip strength in elderly people |
gene:3; variant:2; population:65,105 |
| 502 |
Cortisol suppression by dexamethasone in the healthy elderly: effects of age, dexamethasone levels, and cognitive function |
subject:3,9.1,33; suppressor:30; age:0.4,41; score:-0.45; variance:44,47; r:-0.72 |
| 503 |
Cell replication and aging: in vitro and in vivo studies |
approach:2 |
| 504 |
Age and sex differences in body size and composition during rhesus monkey adulthood |
adult:15,19,41; category:6; year:6,9,26,30; group:2 |
| 505 |
Serum levels of cathepsin D, sirtuin1, and endothelial nitric oxide synthase are correlatively reduced in elderly healthy people |
subject:30,90; men:62; woman:28; group:3; arginine:14; citrulline:14 |
| 506 |
A trans-omic Mendelian randomization study of parental lifespan uncovers novel aging biology and therapeutic candidates for chronic diseases |
lifespan:1000000; gene:135638 |
| 507 |
Transcriptome-wide association study of inflammatory biologic age |
biomarkers:9; examination:8,2005,2008; array:1; participant:2386; woman:55; gene:6,146,302,448 |
| 508 |
Physical activity and telomere length in early stage breast cancer survivors |
woman:392; group:2; coefficient:-0.41,-0.22,-0.03,95; p:0.05 |
| 509 |
Social interactions and activity patterns of old Barbary macaques: Further insights into the foundations of social selectivity |
female:46; year:5,29 |
| 510 |
Functional Age Predicted by Electronic Short Physical Performance Battery Can Detect Frailty Status in Older Adults |
n:834; year:51,77.2,95; patient:117,717; item:45; score:0,1.98,4,83.61; time:0.23,5; speed:5.21; r2:0.233; p:0.001; index:0.25; age:0.637,0.912; specificity:94.4 |
| 511 |
Human plasma paraoxonase 1 (PON1) arylesterase activity during aging: correlation with susceptibility of LDL oxidation |
paraoxonase:1; year:20,81 |
| 512 |
Treatment of cartilage proteoglycan aggregate with hydrogen peroxide. Relationship between observed degradation products and those that occur naturally during aging |
exposure:1; treatment:2; cleavage:3,5 |
| 513 |
Neuron numbers in locus coeruleus do not change with age in Fisher 344 rat |
rat:344; month:12,32 |
| 514 |
Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span |
set:2; pc:20 |
| 515 |
Human aging is associated with parallel reductions in insulin and amylin release |
diabetes:2; yr:1,2,9,10,25,72; airmax:-2,0.001,0.52,2.9,4.03,6.85,10,12.7,25; si:-4,2.2,4.6,10; subject:0.8; min-1:-5,-4,0.59,0.95,1.4,2.46,8.6,10; p:-2,0.001,0.01,0.05,10,63; glucose:420; aarg:1.5,1.7,6.5,9,87,106,203,307,537,1096,1572; aarmax:0.52,2.4,3.5,4.71,13.5,14,16.5; airg:0.29,1.54,4.1; response:0; ratio:1.4,1.5 |
| 516 |
Neural stem cells improve neuronal survival in cultured postmortem brain tissue from aged and Alzheimer patients |
cell:14 |
| 517 |
The EpiTect Methyl qPCR Assay as novel age estimation method in forensic biology |
change:4; subject:80; year:7.2,11,18,91 |
| 518 |
Decreased adrenal androgen sensitivity to ACTH during aging |
test:24 |
| 519 |
Hypoglycemia counterregulation in elderly humans: relationship to glucose levels |
glucose:2; age:1,11,13,24,65; hormone:1; occasion:2; volunteer:1; euglycemia:60,70; study:1,2,50,60; p:0.005,0.02,0.05; mg:50,60; dl:50 |
| 520 |
Age prediction of children and adolescents aged 6-17 years: an epigenome-wide analysis of DNA methylation |
year:0.23,0.62,6,17; individual:180; cpgs:83,6350; n:89,90,179; site:49,83,116; correlation:0.93,0.99; predictor:2,83; illumina:450 |
| 521 |
Age-associated changes in amyloid- and formaldehyde concentrations in cerebrospinal fluid of rhesus monkeys |
formation:2018,2019; level:40,42; monkey:56; year:4,26; decline:40,42; concentration:40,42 |
| 522 |
Human age-declined saliva metabolic markers determined by LC-MS |
volunteer:27; subject:13,14; metabolite:7,99; fold:1.96; compound:14 |
| 523 |
Endothelial cell senescence in human atherosclerosis: role of telomeres in endothelial dysfunction |
icam:-1 |
| 524 |
Blunted increases in skin sympathetic nerve activity are related to attenuated reflex vasodilation in aged human skin |
adult:0.01,1,13,67; response:2; se:1,13,23; yr:2; p:0.001,0.01,0.05,0.08; r2:0.02,0.05,0.76,0.87 |
| 525 |
Quantitative aspects of glucose production and metabolism in healthy elderly subjects |
glucose:6; woman:24,75; men:3,4; kg-1min-1:4; rate:0.06,2.18,2.41; mg:0.05,4; p:0.05; group:2 |
| 526 |
Long Telomeres Do Not Affect Cellular Fitness in Yeast |
time:5; telomere:5 |
| 527 |
Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women |
hallmark:2; adult:53; year:50,86; min:6; age:50,86; increase:18; number:10.4,22.6 |
| 528 |
Leisure-time physical activity and DNA methylation age-a twin study |
ci:-1.17,19,26,35,37,47,53,63,65,74,82,95; p:0.001; mz:7; pair:9; age:60.7 |
| 529 |
Selected contribution: Bone adaptation with aging and long-term caloric restriction in Fischer 344 x Brown-Norway F1-hybrid rats |
fischer:344; aging:1990; sci:51,54,59,1996; adult:8; n:6; mo:28,36; age:5; senescence:6,36; rat:6; vertebra:6 |
| 530 |
Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men |
min:2.5; age:8,10,21,34; men:0.058,0.29,1.607,2.9,62,72; l:0.31,3.1; set:3; p:0.0001,0.0005,0.0046,0.022,0.086,1.223,1.902; apen:0.085,1.744; volunteer:0.084,1.346 |
| 531 |
Quantitative mapping of human hair greying and reversal in relation to life stress |
rosenberg:100 |
| 532 |
A network-based meta-analysis for characterizing the genetic landscape of human aging |
gene:6600; datasets:35; cluster:1000 |
| 533 |
Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey |
rhesus:14; year:1,4,6,17,24,29,31; monkey:4; aberration:5,6,28,71 |
| 534 |
Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from aging humans |
kda:170 |
| 535 |
Presbyopia - a maverick of human aging |
year:120 |
| 536 |
Olfactory phenotypic expression unveils human aging |
participant:622; year:5,105; concentration:9; phenotype:3 |
| 537 |
Does a retrograde response in human aging and longevity exist? |
group:3; year:20,49,50,80; haplogroup:0.012 |
| 538 |
Temporal lobe in human aging: A quantitative protein profiling study of samples from Chinese Human Brain Bank |
plex:4; group:4; year:625,844,951,3413; protein:67,109,5072 |
| 539 |
Failed compensatory dendritic growth as a pathophysiological process in Alzheimer's disease |
area:2 |
| 540 |
Circulating miR-19a-3p and miR-19b-3p characterize the human aging process and their isomiRs associate with healthy status at extreme ages |
donor:12,49; group:4; rna:79; mirs:2; target:3 |
| 541 |
Aging and body composition: the sarcopenic obesity in Spain |
year:65,2050; s:90; value:15 |
| 542 |
Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts |
patient:12 |
| 543 |
Standard organ weights among elderly Japanese who died in hospital, including 50 centenarians |
case:1615; year:60,99,1995,2003; centenarian:50,1973,2005; organ:9; value:99 |
| 544 |
Increased expression of mature cathepsin B in aging rat liver |
p:0.001 |
| 545 |
Gene expression, fiber type, and strength are similar between left and right legs in older adults |
men:8; year:2,71; nlogp:2,31; gene:0.6,5499; domain:1.5; fold:1.5 |
| 546 |
A possible effect of montelukast on neurological aging examined by the use of register data |
test:7; f:2.2; p:0.03 |
| 547 |
Proteins induced by telomere dysfunction are associated with human IgA nephropathy |
individual:260; marker:4; plasma:88.2,92.5; urine:74.3,84.2 |
| 548 |
A new mechanism for aging: chemical "age spots" in immortal DNA strands in distributed stem cells |
observation:2 |
| 549 |
Renin-angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression |
enalapril:10,30; month:16.5 |
| 550 |
microRNA-496 - A new, potentially aging-relevant regulator of mTOR |
mir:-496; site:2; utr:3; transcript:3; level:40 |
| 551 |
Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys |
monkey:30; m:99 |
| 552 |
Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its relationship to the severe clinical phenotypes |
patient:10,86; colon:8; case:10; p:0.0001,0.003,0.01,0.043; time:2 |
| 553 |
Comparative endocrinology of aging and longevity regulation |
decade:2 |
| 554 |
A defined human aging phenome |
individual:76000000 |
| 555 |
Use of antiarrhythmic drugs in elderly patients |
age:60; ca:2 |
| 556 |
Alterations of monocyte NF-B p65/RelA signaling in a cohort of older medical patients, age-matched controls, and healthy young adults |
day:30; control:20,52,60; mfi:81,125; iqr:70,71,80,86,90,105,153; p:0.0001,0.02,0.33,0.72; ratio:0.1; ci:0,0.0001,0.05,0.08,0.1,0.12,0.13,0.15,0.27,0.35,0.4,95; stimulation:0.02,0.05 |
| 557 |
Age and poverty status alter the coding and noncoding transcriptome |
cell:16; profiling:16; gas5:40; meg3:3262 |
| 558 |
Role of mineralocorticoid receptors in arterial stiffness in human aging |
adult:23; year:641; placebo:0.9; leg:0.5; arm:0.3; carotid:0.7; mmhg:2; distensibility:0.8; kpa:-3,10; index:0.8; p:0.6,0.8 |
| 559 |
Simultaneous increase of mitochondrial DNA deletions and lipid peroxidation in human aging |
bp:4977,7436 |
| 560 |
Monoclonal gammopathies in human aging: increased occurrence with age and correlation with health status |
subject:439; year:25,34,75,84; group:4 |
| 561 |
Brain monoaminergic and neuropeptidergic variations in human aging |
hydroxytryptamine:5; ht:5; acid:5,34; l:5; precursor:5; subject:23; year:16,75; concentration:5 |
| 562 |
Larger nondeclarative than declarative deficits in learning and memory in human aging |
participant:80; paradigm:1,2; m:400,750 |
| 563 |
Altered memory B-cell homeostasis in human aging |
subject:11; resident:173; adult:34 |
| 564 |
Epigenetic signature: implications for mitochondrial quality control in human aging |
datasets:2; individual:381,468; predictor:12; site:2,10 |
| 565 |
Global mapping of transcription factor motifs in human aging |
site:18; model:7 |
| 566 |
Onset of human aging estimated from hazard functions associated with various causes of death |
survival:1978,1983; cause:5; age:4; period:2; year:5,20,30,35 |
| 567 |
Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging |
data:1; intervention:2 |
| 568 |
The relationship of cytomegalovirus (CMV) infection with circulatory IFN- levels and IL-7 receptor expression on CD8+ T cells in human aging |
age:40,65 |
| 569 |
Human aging reduces the neurobehavioral influence of motivation on episodic memory |
adult:19,21; hour:24 |
| 570 |
Interleukin 2 receptor expression by T cells in human aging |
receptor:2; year:39,65; p:0.033; pair:8; affinity:0.2,1586,1850,20655,23466 |
| 571 |
Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions--a strategy in translational psychopharmacology |
ht1a:5; subject:24; year:20,55; bp:5 |
| 572 |
Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution |
year:100,122.5,200; century:21; acceleration:50 |
| 573 |
Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series |
conference:3; j:433 |
| 574 |
Imbalance of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 is associated with pulmonary emphysema in Klotho mice |
expression:-2; timp:-1,2; week:2,5 |
| 575 |
Integrative Analysis of Global Gene Expression Identifies Opposite Patterns of Reactive Astrogliosis in Aged Human Prefrontal Cortex |
study:4; year:2040,5880; gene:1817 |
| 576 |
Aging and disease-relevant gene products in the neuronal transcriptome of the great pond snail (Lymnaea stagnalis): a potential model of aging, age-related memory loss, and neurodegenerative diseases |
deglycase:7 |
| 577 |
Platelet aging in vivo is associated with loss of membrane phospholipid asymmetry |
condition:2; subpopulation:1; platelet:2; proportion:8,11.3; p:0.05,3.7,5.2; day:10,12.3,17.7 |
| 578 |
Quantitative allele-specific PCR: demonstration of age-associated accumulation in human tissues of the A-->G mutation at nucleotide 3243 in mitochondrial DNA |
parameter:3; detection:0.01; g:3243; mtdna:10; a--:3243 |
| 579 |
Stress and telomere shortening among central Indian conservation refugees |
sahariya:1998,2002; village:2; n:24; analytes:2 |
| 580 |
Age-related 4,977 bp deletion in human lung mitochondrial DNA |
pair:4977; mtdna:4977; specimen:127; gestation:34; yr:39,79; biopsy:60.6,77; decade:4; p:0.0001,0.005; proportion:0.007,0.33 |
| 581 |
Telomere length in non-neoplastic gastric mucosa and its relationship to H. pylori infection, degree of gastritis, and NSAID use |
subject:151; user:49; nonusers:102; p:0.0002,0.002,0.028; value:0.01 |
| 582 |
Increased superoxide anion production in humans: a possible mechanism for the pathogenesis of hypertension |
volunteer:335; year:2,20,34,59,60,67,75,76; patient:30; difference:250,1814.35; u:126.19,139.5,1322.4,1584.06; p:0.001,0.05; group:2 |
| 583 |
Reduced baroreflex sensitivity in elderly humans is not due to efferent autonomic dysfunction |
age:10; year:22,30.5,40,67,70.7,75; male:6,10; volunteer:5; test:4; group:7,13; br:29; m:-0.74; p:-1.13,0.001,84 |
| 584 |
DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross-Sectional Study in Mice and Humans |
month:4,20; human:18,50; dnase:1 |
| 585 |
Protein signatures from blood plasma and urine suggest changes in vascular function and IL-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort |
cohort:2; range:70,82; cytokine:9,40; protein:2,8,23,500; value:0.01,0.025,1.5; timepoints:2; pattern:86; case:60; receptor:4 |
| 586 |
Intact Reinforcement Learning But Impaired Attentional Control During Multidimensional Probabilistic Learning in Older Adults |
task:2 |
| 587 |
Short-term zinc supplementation of zinc-deficient seniors counteracts CREM - mediated IL-2 suppression |
production:-2; subject:23,31 |
| 588 |
Feedback-Based Learning in Aging: Contributions and Trajectories of Change in Striatal and Hippocampal Systems |
finding:3 |
| 589 |
Short-term testosterone manipulations do not affect cognition or motor function but differentially modulate emotions in young and older male rhesus monkeys |
monkey:10; age:19; range:15,25; male:6; al:2009; week:4,8; g:200; kg:8,20 |
| 590 |
L-cysteine influx in erythrocytes as a function of human age |
acid:3; cysteine:10 |
| 591 |
Carbonyl formation in erythrocyte membrane proteins during aging in humans |
subject:49; year:17,80; p:0.0001; r:0.0001,0.8269 |
| 592 |
An ethical assessment of anti-aging medicine |
argument:4,6; inequity:1; immutability:3; overpopulation:4; ennui:5; ageism:6; beneficence:1; death:2; autonomy:3; quality:4; proposition:2 |
| 593 |
Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy individuals |
receptor:4; myd88:88; research:90; men:63; woman:27; age:30 |
| 594 |
Tandem duplications and large-scale deletions of mitochondrial DNA are early molecular events of human aging process |
type:10; group:3; bp:4977,7436; deletion:2 |
| 595 |
Debate on human aging and lifespan |
year:115 |
| 596 |
How We Fall Apart: Similarities of Human Aging in 10 European Countries |
wave:4; deficit:2.5; year:2.6,102 |
| 597 |
Comment on "The plateau of human mortality: Demography of longevity pioneers" |
june:29,2018; report:1459; age:105; year:122 |
| 598 |
The function of vascular smooth muscle phosphodiesterase III is preserved in healthy human aging |
pgi:2; subject:10; control:10; mldl:-1,0.81,6.88; favmin:-1 |
| 599 |
Body water compartments with human aging using fat-free mass as the reference standard |
men:16,39,45,59; measurement:2; subject:704; decrease:4,5 |
| 600 |
A positive aging framework for guiding geropsychology interventions |
characteristic:4 |
| 601 |
mir-24 activity propagates stress-induced senescence by down regulating DNA topoisomerase 1 |
mirnas:2 |
| 602 |
Rules for the use of model organisms in anti-aging pharmacology |
data:1,2; model:3,4; fertility:5; depression:6; environment:7 |
| 603 |
Effects of intra- and extracellular factors on anti-aging klotho gene expression |
kbp:2.1 |
| 604 |
Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene |
vntr2:1; bp:42 |
| 605 |
Increased genome instability is not accompanied by sensitivity to DNA damaging agents in aged yeast cells |
cell:25 |
| 606 |
Gravitational artefact in frequency spectra of movement acceleration: implications for actigraphy in young and elderly subjects |
signal:3; hz:0.25,0.5,2,3,11 |
| 607 |
Neuroaxonal dystrophy in aging human sympathetic ganglia |
adult:56 |
| 608 |
An ESIPT-based two-photon fluorescent probe detection of hydrogen peroxide in live cells and tissues |
intensity:45; m:70,170; nm:720 |
| 609 |
Three-dimensional microstructure of the bone in a hamster model of senile osteoporosis |
month:3,6,12,18,24 |
| 610 |
Developmental immunolocalization of the Klotho protein in mouse kidney epithelial cells |
day:18,20,21; week:3; cnt:2 |
| 611 |
Altered NGF response but not release in the aged septo-hippocampal cholinergic system |
mechanism:2; minute:15 |
| 612 |
A Method to Train Marmosets in Visual Working Memory Task and Their Performance |
marmoset:13; trial:476,1316 |
| 613 |
Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults |
cohort:227; mm3:2497.5,2579.8 |
| 614 |
HRV Monitoring Using Commercial Wearable Devices as a Health Indicator for Older Persons during the Pandemic |
march:2020; november:2021; people:10; train:75 |
| 615 |
Role of the JAK2/STAT pathway and losartan in human glomerular mesangial cell senescence |
stat1:3; pathway:3 |
| 616 |
Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism |
month:2,3.5,23,23.5,30 |
| 617 |
Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data |
individual:1000; snp:2,13,378; model:2; auc:0.873; grade:3; greying:0.875; variant:10 |
| 618 |
Activin subfamily peptides predict chronological age in humans |
decade:3; gdf11:11; participant:88; p:0.032,0.046; r2:0.048,0.053 |
| 619 |
Renormalized basal metabolic rate describes the human aging process and longevity |
rmsbmr:25425 |
| 620 |
Size discrimination in adult zebrafish (Danio rerio): Normative data and individual variation |
ratio:0.6,0.75,0.91 |
| 621 |
Aging of human glyceraldehyde-3-phosphate dehydrogenase is dependent on its subcellular localization |
kda:37 |
| 622 |
Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging |
minute:10; subject:9,10; year:2,27,71 |
| 623 |
A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes |
polypeptide:8; wfikkn1:1,2,69.2,96.4; protein:5,10.9,21.3; peptide:18; transition:54; adult:24; gdf8:2.4,11; propeptide:8,25.7; fst:12.4,16.5; form:7.1,29.8; wfikkn2:8.3,38.3; oxytocin:0.5,2.3,10.5,32.2; eotaxin:0.9,1.9 |
| 624 |
Human aging alters the first phase of the molecular response to stress in T-cells |
year:20,40,70; reduction:66; degree:42 |
| 625 |
Quercetin Mitigates Red Blood Cell Membrane Bound Na+, K+-ATPase Transporter During Human Aging |
quercetin:6,10; presence:3,10; increase:15; m:3,4,5,6,7,10,17,31,39,51,61; concentration:6,10 |
| 626 |
Reduced brain delivery of homovanillic acid to cerebrospinal fluid during human aging |
aliquot:4,5; ml:6; l4:5; age:7; subject:28.7,77.1; year:4.6,6.3; mean:7; pmol:66,86,116,140,640,704; rate:294,591; d:175,416; decline:50 |
| 627 |
Donor age reflects the replicative lifespan of human fibroblasts in culture |
year:27,36,62; time:4; line:8 |
| 628 |
Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity |
neuron:5; microcircuit:5 |
| 629 |
Cross-species functional modules link proteostasis to human normal aging |
level:3; trait:22 |
| 630 |
DNA methylation clocks for dogs and humans |
breed:93; specie:2; r:0.97 |
| 631 |
Ascorbic acid, glycation, glycohemoglobin and aging |
month:2,3; g:20; micromol:30 |
| 632 |
Macular degeneration in a community of rhesus monkeys. Ultrastructural observations |
adult:29; year:20; sample:25 |
| 633 |
Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca2+/CaMKII signal pathway |
light:1; chain:3 |
| 634 |
Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans |
elegans:6; n2:10,28,56,57,66,137; p:-33,4e-05,0.0001,0.00012,0.0003,0.001,0.0034,0.0039,0.0138,0.0225,0.05; i:10,18,26,43,74; acid:11; ifd:-68 |
| 635 |
The effects of long-term stress exposure on aging cognition: abehavioral and EEG investigation |
task:2 |
| 636 |
Genetic basis of age-dependent synaptic abnormalities in the retina |
chromosome:7,19 |
| 637 |
Aging and insulin sensitivity: role of blood pressure and sympathetic nervous system activity |
subject:60; year:19,78 |
| 638 |
Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus) |
assessment:3; year:1; decline:1; age:2; performance:3 |
| 639 |
Zinc supplementation can reduce accumulation of cadmium in aged metallothionein transgenic mice |
reduction:30 |
| 640 |
Ultra-weak photon emission of hands in aging prediction |
subject:11,49,60; area:4; pmt:2; r:0.6; square:0.4; p:9.4e-07,49,60 |
| 641 |
Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults |
mirs:10; year:80; p:-0.43,-0.36,0.001 |
| 642 |
Antioxidant phenolic compounds isolated from wild Pyrus ussuriensis Maxim. fruit peels and leaves |
compound:13; picrylhydrazyl:11; rutin:1,2; orobol:3,5,7; daidzein:4; threo:4; o:3,7; trilobatin:9; hydroxyphenyl:4; trihydroxyphenyl:10; rhamnopyranoside:11; apigenin:12; quercetin:3,13; g:6.06,9.6 |
| 643 |
A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1 |
efemp1:1; copyright:2018 |
| 644 |
One month of contemporary dance modulates fractal posture in aging |
participant:38; year:54,89; week:4; time:3 |
| 645 |
Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults |
adult:22; year:53,79,611; dilation:0.4; eplerenone:100; dos:2; placebo:0.02; p:0.02,0.5,2,135,774; mmhg:2,134,774 |
| 646 |
Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging |
day:5; microgram:30; h:12,18,20; crh:50; combination:50; month:3,6,20,24; level:23.2,77.6; p:0.01,0.05,2230,3670 |
| 647 |
A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians |
vntr:3; repeat:35,39; subject:40,409; year:20,102; genotype:3; allele:-5.98; interval:-8.93,-4.41,-0.74,-0.2,0.21,0.32,0.98,1.6,95; h:0.75 |
| 648 |
Is human aging still mysterious enough to be left only to scientists? |
experimentalists:5; sci:452,462,959 |
| 649 |
Improved Human Age Prediction by Using Gene Expression Profiles From Multiple Tissues |
tissue:2,46; year:3.6,3.92 |
| 650 |
Hypothesis: is yeast a clock model to study the onset of humans aging phenotypes? |
year:30; day:27 |
| 651 |
Antioxidants and Quality of Aging: Further Evidences for a Major Role of TXNRD1 Gene Variability on Physical Performance at Old Age |
snp:9; individual:64,107; variant:3; year:85; rs11111979:0.022; borderline:2 |
| 652 |
The Aging Study of Pyeongchang Rural Area (ASPRA): Findings and Perspectives for Human Aging, Frailty, and Disability |
participant:382 |
| 653 |
Raman spectroscopic evaluation of aging and long-wave UV exposure in the guinea pig lens: a possible model for human aging |
microliter:-3,2,10; point:21; month:9; sulfhydryl:2580; signal:2731; cm-1:622; ratio:21; peak:353 |
| 654 |
Human aging and somatic point mutations in mtDNA: A comparative study of generational differences (grandparents and grandchildren) |
grandmother:3,9,12,13,15,31; year:2.3,4.1,15,60,63; grandchild:62; mutation:3 |
| 655 |
Changes in the autonomic control of the cardiovascular system in human aging. meta-analysis |
work:32; year:275,645; pubmed:32,275,645 |
| 656 |
Multiscale multifractality analysis of a 12-lead electrocardiogram |
lead:12 |
| 657 |
Selective brain regional changes in lipid profile with human aging |
region:13; individual:40; atom:18 |
| 658 |
The role of the glucose transport system in the postreceptor defect in insulin action associated with human aging |
subject:14; yr:2,4,11,40,69; o:3; se:0.17,1.26,1.96; transport:0.025,0.26; pmol:2; cell:5,10; p:0.05,0.54,15 |
| 659 |
Hungry children age faster |
wave:6; percent:20,40 |
| 660 |
Brain Aggregates: An Effective In Vitro Cell Culture System Modeling Neurodegenerative Diseases |
embryo:15 |
| 661 |
Effects of advanced aging on plasma catecholamine responses to the cold pressor test |
age:75,80; subject:8,19,25.4,28,84.4; year:-1.3,-0.9,70.3 |
| 662 |
Klotho gene variation and expression in 20 inbred mouse strains |
strain:3,4,16; variant:45; substitution:4 |
| 663 |
Capit timed tests quantify age-related motor decline in normal subjects |
subject:60; performance:20,87; test:4; point:2; patient:30; fd:0.01; mtp:0.0005; wt:0.0001; p:0.0001 |
| 664 |
A survey of the awareness, knowledge and behavior of hair dye use in a korean population with gray hair |
survey:20; subject:500; dye:73,233; people:319; user:23.8,76,319 |
| 665 |
A microfluidic diode for sorting and immobilization of Caenorhabditis elegans |
characteristic:2; feature:1,2; worm:974 |
| 666 |
B and T Lymphocyte Densities Remain Stable With Age in Human Cortex |
subject:16,40 |
| 667 |
The Ercc1-/ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions |
mouse:4; month:5 |
| 668 |
Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project |
subject:2936; year:35,75; nitrotyrosine:3 |
| 669 |
Age differences in strategy selection and risk preference during risk-based decision making |
fischer:344; strategy:2 |
| 670 |
Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer's, Parkinson's and Huntington's diseases |
type:4; pn200:110; decrease:110 |
| 671 |
Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques |
year:5,30; age:5; week:4 |
| 672 |
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells |
passage:3,13 |
| 673 |
Biomarkers of senescence in non-human primate adipose depots relate to aging |
monkey:43; adult:7; fat:8,53 |
| 674 |
Rapamycin impairs bone accrual in young adult mice independent of Nrf2 |
impact:16; kg:4; vertebra:5 |
| 675 |
Phycoerythrin averts intracellular ROS generation and physiological functional decline in eukaryotes under oxidative stress |
decrease:48,67; treatment:77; glu:52; phycoerythrobilin:5 |
| 676 |
Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2 |
isoform:2; beta:2 |
| 677 |
Effect of aging on CD11b and CD69 surface expression by vesicular insertion in human polymorphonuclear leucocytes |
p:0.01,0.15,43.9,55.3,68.4,73.7; process:2 |
| 678 |
Progressive changes in non-coding RNA profile in leucocytes with age |
year:24,79; rna:69; micrornas:56; snornas:13; range:47,54 |
| 679 |
Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data |
characteristic:2; site:102,48601; individual:610; family:176; decrease:2266 |
| 680 |
Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with ATPase's |
year:20,82; concentration:10; m:-8,-3,10; k:0.8882; ca:2; r:0.954 |
| 681 |
The DNA methylome as a biomarker for epigenetic instability and human aging |
marker:71 |
| 682 |
Relationship between plasma IGF-I levels, in vitro correlates of immunity, and human senescence |
young:34; year:0.9,1.3,27; sem:41,79; male:31; female:44; p:0.001,0.05; r:0.492; type:3 |
| 683 |
The disjunction zone in the slit-image-photograph of the human aging lens (author's transl) |
lens:178 |
| 684 |
Deformability of red blood cells and human aging |
volunteer:50; group:2; year:22,30,75,89; atp:2; ca:2 |
| 685 |
Longevity genomics across species |
gene:100 |
| 686 |
Resilient protein co-expression network in male orbitofrontal cortex layer 2/3 during human aging |
analysis:2,3; subject:15,18,62; protein:2,3,62,4193; size:20,127; effect:0.05; up-:65; communication:54; nutrient:39; proteostasis:35 |
| 687 |
Increase in density and accumulation of serotonin by human aging platelets |
day:1,2,2.5,4,5,6,12,15,500; platelet:7,8,10,13.5,33.8,61; serotonin:9.5,76.8; p:0.001; ng:17.7; volunteer:3 |
| 688 |
Impact of cognitive performance on the functional capacity of an elderly population in Natal, Brazil |
person:213 |
| 689 |
Walking speed as an aging biomarker in baboons (Papio hamadryas) |
baboon:33; year:5,21; p:0.0005; kg:16; cm:0.3,0.6 |
| 690 |
Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis |
peroxiredoxin:3 |
| 691 |
Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging |
day:8,15; mg:1.25,20; microgram:14.1,18,122.4,300; igfbp-3:3; subject:7; male:4; female:3; year:63,67,80; woman:7; kg:1; ghrh:72,229.4,257.6; peptide:42.8,237.8,342.5; i:138.7; treatment:0.2,11.1,156; level:2.4; p:0.02,0.03,3.4; l:0.2,3.1,13.6,141.6; igf:0.2 |
| 692 |
Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans |
shogaol:6 |
| 693 |
The human blood pressure chronome: a biological gauge of aging |
individual:72; year:12,106; day:7; minute:15,60; cycle:1,7,8; group:4 |
| 694 |
Fantastic voyage: live long enough to live forever. The science behind radical life extension questions and answers |
component:3 |
| 695 |
Cellular signalling pathways in immune aging and regeneration |
interleukin:7 |
| 696 |
MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality |
association:100,1576; biomarkers:471 |
| 697 |
Subdental synchondrosis. Computed tomographic and histologic investigation on morphological aspects of fracture at the base of the dens in 36 human axis specimens |
center:2,4; patient:36; persistency:87 |
| 698 |
The Aging Imageomics Study: rationale, design and baseline characteristics of the study population |
participant:1030; year:50,67,96 |
| 699 |
Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males |
test:400 |
| 700 |
Elevation of soluble Fas (APO-1, CD95) ligand in natural aging and Werner syndrome |
patient:14; year:15,33,70,83,95; adult:21; p:0.0001,0.0085,0.024,0.025,0.05 |
| 701 |
Regulation of venous alpha-adrenergic responses in older humans |
alpha:1,2; subject:15; yr:59,73; wk:3; placebo:1; level:1.47; decrease:0.07; p:0.001,0.01,0.6,1,1.4,3,6.1; kinetics:11.8; suppression:2; response:1 |
| 702 |
Association of sleep quality with excessive daytime somnolence and quality of life of elderlies of community |
people:35.9,39.7,131; age:87; wage:2,84.8; education:86.3; relative:67.9; percent:71; risk:38.2; psqi:8.972 |
| 703 |
Effects of aging on encoding of walking direction in the human brain |
confusion:1,2; direction:2 |
| 704 |
Effect of gender on main clinical chemistry parameters in aged rats |
month:24 |
| 705 |
Convergent and Divergent Age Patterning of Gut Microbiota Diversity in Humans and Nonhuman Primates |
population:4; group:2,7; prevotellamassilia:6; metabolite:2,66; bacteria:6; primate:3 |
| 706 |
Profiling of IgG N-glycome during mouse aging: Fucosylated diantennary glycans containing one Neu5Gc-linked LacNAc are associated with age |
mouse:6; time:12; point:6; peak:4; glycans:2; p:0.0001; murine:4; model:6 |
| 707 |
The cortisol awakening response is related with PERIOD1 clock gene expression in older women |
woman:20,30; yr:2.13,5.12,24.4,67.9; min:15,30,45,60; h:800; time:5; p:-0.9,0.001,0.01,0.05,0.39; car:0.798; sem:0.07 |
| 708 |
Effectiveness of a Supervised Group-Based Otago Exercise Program on Functional Performance in Frail Institutionalized Older Adults: A Multicenter Randomized Controlled Trial |
century:21; month:6; frail:111; year:3,5.3,5.9,6,34,75,86; criterion:5; age:84.9,87.3; oep:-7.3,38,39; test:10; minute:6; way:2; second:-8.2,-6.9; ci:-13.3,-12.4,-9.8,0.6,1.5,1.6,95; p:-4,-2.9,-2.2,1.7,2.6,5.2,5.3,5.5,5.9,6.5,7.6,11.2,95; point:3.5,4.3,4.6,8.2; kg:3.4,3.6 |
| 709 |
Are the Pathologic Features of Enthesopathy, Tendinopathy, and Labral and Articular Disc Disease Related to Mucoid Degeneration? A Systematic Review |
study:52,100,1980,2021,3196; article:559; cell:9,10,20; percent:43,52,83; method:14,17,26,40,60; control:3; matrix:36,69; collagen:37,52; metaplasia:17,33,52 |
| 710 |
Human age prediction based on DNA methylation of non-blood tissues |
sample:262,1280; year:0,4.66,6.08,90; site:13; model:3; correlation:0.89 |
| 711 |
ELISA for aging biomarkers induced by telomere dysfunction in human plasma |
person:50; year:25,78; time:3; hour:3 |
| 712 |
Genome-wide prediction and prioritization of human aging genes by data fusion: a machine learning approach |
database:11; candidate:3000 |
| 713 |
Identification of co-evolving temporal networks |
network:2; topology:2; subnetworks:2 |
| 714 |
The Association of a Single-Nucleotide Polymorphism in the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene With Adverse Drug Reactions, Multimorbidity, and Frailty in Older People |
factor:2; year:18,80; locus:3; week:8 |
| 715 |
How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data |
variant:24; snp:24 |
| 716 |
Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease |
polymorphism:11.4,360; n:120; distribution:119; p:0.005,5.7; year:8.46,9.69,39,74.29; apoaiv:360 |
| 717 |
Human aging brain disorders: role of antioxidant enzymes |
enzyme:2; activity:1,2 |
| 718 |
Human aging alters social inference about others' changing intentions |
level:2 |
| 719 |
Population biology of human aging: segregation analysis of bone age characteristics |
allele:2; hypothesis:50,60; frequency:30,38 |
| 720 |
Population biology of human aging: methods of assessment and sex variation |
individual:7000; group:2,32; year:16,99; r:0.001,0.78,0.8; parameter:3 |
| 721 |
Aging and the human zona reticularis |
victim:42; month:4; year:93 |
| 722 |
Does telomere length affect blood pressure? |
volunteer:37; year:50 |
| 723 |
Critical analysis of the applicability of the Gompertz-Makeham law in human populations |
country:35; year:5,35,75 |
| 724 |
Progressive supranuclear palsy and Parkinson's disease overlap: A clinicopathological case report |
year:13 |
| 725 |
Generative acts: family and community involvement of older Australians |
theme:2 |
| 726 |
Comparison between subjective and objective methods for sodium intake estimate among hypertensive persons |
year:50; hour:24; h:24 |
| 727 |
Lifetime data analysis of disease and aging by the Weibull probability distribution |
period:2,3 |
| 728 |
Mitochondrial DNA4977 deletions associated with human presbycusis |
side:67; brain:20; cochlear:21; heart:20; liver:22; segment:1; p:0.05 |
| 729 |
Age-related effects of vagotonic atropine on cardiovagal baroreflex gain |
subject:14,16; gain:30; component:20 |
| 730 |
DKC1 gene mutation in a Taiwanese kindred with X-linked dyskeratosis congenita |
year:19,20; c:1058 |
| 731 |
Describing the natural heterogeneity of aging using multilevel regression models |
year:35 |
| 732 |
Age and gender effect on the growth of bone marrow stromal cells in vitro |
patient:38; men:14; woman:11,24,70; sample:6.7,15; year:40,59; percent:16,23,70 |
| 733 |
A study on the basic nature of human biological aging processes based upon a hierarchical factor solution of the age-related physiological variables |
individual:462; day:2; variable:27; factor:1,3,6,16 |
| 734 |
Dehydroepiandrosterone and Bone |
mapk:44 |
| 735 |
Assessing genetic association with human survival at multi-allelic loci |
yashin:1999; genet:65,1178,1193 |
| 736 |
A high fat, sugar, and salt Western diet induces motor-muscular and sensory dysfunctions and neurodegeneration in mice during aging: Ameliorative action of metformin |
mouse:6; phase:56 |
| 737 |
X-ray diffraction studies on human tendon show age-related changes in collagen packing |
year:1.6,60,87; reflection:67 |
| 738 |
Methionine Restriction Improves Gut Barrier Function by Reshaping Diurnal Rhythms of Inflammation-Related Microbes in Aged Mice |
month:3; h:24; tm7:3 |
| 739 |
Longitudinal study of sleep and diurnal rhythms in Drosophila ananassae |
post:2; h:24 |
| 740 |
High levels of objectively measured physical activity across adolescence and adulthood among the Pokot pastoralists of Kenya |
participant:14,40 |
| 741 |
Gene expression profiling of the SCN in young and old rhesus macaques |
h:24; scn:1; member:1; year:7,12,21,26 |
| 742 |
Differential effects of age and executive functions on the resolution of the contingent negative variation: a reexamination of the frontal aging theory |
volunteer:15,19; function:1 |
| 743 |
Plasma catecholamine and cardiovascular responses to physostigmine in Alzheimer's disease and aging |
physostigmine:0.0125; response:1,2; age:-2,-1,9,11,20,27,71,72; yr:-2; score:19 |
| 744 |
Thermoregulatory reflex control of cutaneous vasodilation in healthy aging |
adult:0.005,13; p:-1,0.002,0.007,0.01 |
| 745 |
Fatty acid-induced production of plasminogen activator inhibitor-1 by adipose macrophages is greater in middle-aged versus younger adult participants |
participant:31 |
| 746 |
F-XTRA PET for Enhanced Imaging of the Extrathalamic 42 Nicotinic Acetylcholine Receptor |
acetylcholine:42; nachr:42; adult:17; men:11; woman:6; y:30,82; min:10,70,90,180; compartment:2; tissue:1 |
| 747 |
Low frequency mitochondrial DNA heteroplasmy SNPs in blood, retina, and [RPE+choroid] of age-related macular degeneration subjects |
tissue:3; subject:3; range:1000,30000,100000; snp:2,5,23; sample:222; heteroplasmy:4,40; p:0.008; change:3; t:222 |
| 748 |
MicroRNA profiling of different exercise interventions for alleviating skeletal muscle atrophy in naturally aging rats |
month:24; p:0.001,0.01,0.05; mirnas:13,201,764; network:505; change:1; group:2,7,11; dem:4; hub:6 |
| 749 |
Simultaneous changes in visual acuity, cortical population receptive field size, visual field map size, and retinal thickness in healthy human aging |
adult:20,50 |
| 750 |
Diurnal relationship between core clock gene BMAL1, antioxidant SOD1 and oxidative RNA/DNA damage in young and older healthy women |
woman:21; h:4,24; p:0.001,0.005,0.01,0.02,0.84; r:0.81 |
| 751 |
Correlation Between Telomere Length and Biomarkers of Oxidative Stress in Human Aging |
subject:105; year:20,77; decline:0.001; r:0.8209,0.8811; malondialdehyde:-0.7191 |
| 752 |
Human aging in the post-GWAS era: further insights reveal potential regulatory variants |
snp:291,600; score:1,3,6,291; evidence:4 |
| 753 |
Why aging research? The moral imperative to retard human aging |
society:1; cancer:2 |
| 754 |
Morphometric study of variations related to human aging in pulp unmyelinated and myelinated axons |
fiber:2684; subject:16; year:10,72; zone:9.8; mu:1.96; micron:0.1,0.25,0.35,0.52,2; comparative:0.5,1; cr:-3,0.63; p:8,8.1 |
| 755 |
Qualitative and quantitative alterations in intracellular and membrane glycoproteins maintain the balance between cellular senescence and human aging |
glycoprotein:2,3; glycans:2 |
| 756 |
Influence of Dietary Capsaicin on Redox Status in Red Blood Cells During Human Aging |
capsaicin:8,10; concentration:-5,10; min:60; effect:-5; increase:0.01 |
| 757 |
Intracellular uptake of (-)epicatechin by human erythrocytes as a function of human age |
decrease:0.001 |
| 758 |
Two-photon imaging of oxidative stress in living erythrocytes as a measure for human aging |
group:3; p:0.001,0.05 |
| 759 |
Mechanical properties of anterior lens capsule assessed with AFM and nanoindenter in relation to human aging, pseudoexfoliation syndrome, and trypan blue staining |
year:48,93 |